Structure of PDB 7msm Chain x Binding Site BS05

Receptor Information
>7msm Chain x (length=553) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEFIYTMKKVRKAHGDKVILDDVTLSFYPGAKIGVVGPNGAGKSSVLRIM
AGLDKPNNGDAFLATGATVGILQQEPPLNEDKTVRGNVEEGMGDIKIKLD
RFNEVAELMATDYTDELMEEMGRLQEELDHADAWDLDAQLEQAMDALRCP
PADEPVTNLSGGERRRVALCKLLLSKPDLLLLDEPTNHLDAESVQWLEQH
LASYPGAILAVTHDRYFLDNVAEWILELDRGRAYPYEGNYSTYLEKKAER
LAVQGRKDAKLQKRLTEELAWVRSGAKARQAKSKARLQRYEEMAAEAEKT
RKLDFEEIQIPVGPRLGNVVVEVDHLDKGYDGRALIKDLSFSLPRNGIVG
VIGPNGVGKTTLFKTIVGLETPDSGSVKVGETVKLSYVDQARAGIDPRKT
VWEVVSDGLDYIQVGQTEVPSRAYVSAFGFKGPDQQKPAGVLSGGERNRL
NLALTLKQGGNLILLDEPTNDLDVETLGSLENALLNFPGCAVVISHDRWF
LDRTCTHILAWEGDDDNEAKWFWFEGNFGAYEENKVERLGVDAAVTHRKL
TRG
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain7msm Chain x Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7msm Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis.
Resolution2.79 Å
Binding residue
(original residue number in PDB)		N159 S161 E164 Y331 G357 V358 G359 K360 T361 T362
Binding residue
(residue number reindexed from 1)		N158 S160 E163 Y330 G356 V357 G358 K359 T360 T361
Annotation score5
Enzymatic activity
Enzyme Commision number 3.6.1.-
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0019843 rRNA binding
GO:0043022 ribosome binding
Biological Process
GO:0006412 translation
GO:0006417 regulation of translation
GO:0045900 negative regulation of translational elongation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7msm, PDBe:7msm, PDBj:7msm
PDBsum7msm
PubMed35064151
UniProtP9WQK3|ETTA_MYCTU Energy-dependent translational throttle protein EttA (Gene Name=ettA)

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