Structure of PDB 6hu9 Chain a Binding Site BS05

Receptor Information
>6hu9 Chain a (length=534) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVQRWLYSTNAKDIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLHG
NSQLFNVLVVGHAVLMIFFLVMPALIGGFGNYLLPLMIGATDTAFPRINN
IAFWVLPMGLVCLVTSTLVESGAGTGWTVYPPLSSIQAHSGPSVDLAIFA
LHLTSISSLLGAINFIVTTLNMRTNGMTMHKLPLFVWSIFITAFLLLLSL
PVLSAGITMLLLDRNFNTSFFEVSGGGDPILYEHLFWFFGHPEVYILIIP
GFGIISHVVSTYSKKPVFGEISMVYAMASIGLLGFLVWSHHMYIVGLDAD
TRAYFTSATMIIAIPTGIKIFSWLATIHGGSIRLATPMLYAIAFLFLFTM
GGLTGVALANASLDVAFHDTYYVVGHFHYVLSMGAIFSLFAGYYYWSPQI
LGLNYNEKLAQIQFWLIFIGANVIFFPMHFLGINGMPRRIPDYPDAFAGW
NYVASIGSFIATLSLFLFIYILYDQLVNGLNNKVNNKSVIYNKAPDFVES
NTIFNLNTVKSSSIEFLLTSPPAVHSFNTPAVQS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6hu9 Chain a Residue 605 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6hu9 Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc1.
Resolution3.35 Å
Binding residue
(original residue number in PDB)		H368 D369
Binding residue
(residue number reindexed from 1)		H368 D369
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H62 D92 W127 S157 S158 H241 E243 Y245 S256 H290 H291 T316 K319 R438
Catalytic site (residue number reindexed from 1) H62 D92 W127 S157 S158 H241 E243 Y245 S256 H290 H291 T316 K319 R438
Enzyme Commision number 7.1.1.9: cytochrome-c oxidase.
Gene Ontology
Molecular Function
GO:0004129 cytochrome-c oxidase activity
GO:0005515 protein binding
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0006119 oxidative phosphorylation
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen
GO:0009060 aerobic respiration
GO:0015990 electron transport coupled proton transport
GO:0045333 cellular respiration
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0045277 respiratory chain complex IV

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hu9, PDBe:6hu9, PDBj:6hu9
PDBsum6hu9
PubMed30598554
UniProtP00401|COX1_YEAST Cytochrome c oxidase subunit 1 (Gene Name=COX1)

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