Structure of PDB 7fin Chain R Binding Site BS05

Receptor Information
>7fin Chain R (length=380) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QTAGELYQRWERYRRECQETLAAAACNGSFDMYVCWDYAAPNATARASCP
WYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILE
RLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAA
AILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLL
VEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQ
CWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDY
RLRLARSTLFLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQG
FLVSVLYCFINKEVQSEIRRGWHHCRLRRS
Ligand information
Ligand IDGGL
InChIInChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKeyWHUUTDBJXJRKMK-VKHMYHEASA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.2C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.2C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370N[CH](CCC(O)=O)C(O)=O
FormulaC5 H9 N O4
NameGAMMA-L-GLUTAMIC ACID;
L-GLUTAMIC ACID
ChEMBLCHEMBL575060
DrugBankDB00142
ZINCZINC000001482113
PDB chain7fin Chain P Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7fin Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		E135 Q138
Binding residue
(residue number reindexed from 1)		E100 Q103
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005515 protein binding
GO:0008528 G protein-coupled peptide receptor activity
GO:0016519 gastric inhibitory peptide receptor activity
GO:0017046 peptide hormone binding
GO:0120022 glucagon family peptide binding
Biological Process
GO:0002029 desensitization of G protein-coupled receptor signaling pathway
GO:0006091 generation of precursor metabolites and energy
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007584 response to nutrient
GO:0009749 response to glucose
GO:0031018 endocrine pancreas development
GO:0032024 positive regulation of insulin secretion
GO:0038192 gastric inhibitory peptide signaling pathway
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0048678 response to axon injury
GO:0050796 regulation of insulin secretion
GO:0051592 response to calcium ion
GO:0070542 response to fatty acid
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7fin, PDBe:7fin, PDBj:7fin
PDBsum7fin
PubMed35217653
UniProtP48546|GIPR_HUMAN Gastric inhibitory polypeptide receptor (Gene Name=GIPR)

[Back to BioLiP]