Structure of PDB 7tf6 Chain N Binding Site BS05

Receptor Information

>7tf6 Chain N (length=438) Species: 1280 (Staphylococcus aureus)

TFTKEDIRKFAEEENVRYLRLQFTDILGTIKNVEVPVSQLEKVLDNEMMF
DGSSIEGFVRIEESDMYLHPDLDTWVIFPWGKVARLICDVYKTDGTPFEG
DPRANLKRVLKEMEDLGFTDFNLGPEPEFFLFKLDEKGEPTLELNDDGGY
FDLAPTDLGENCRRDIVLELEDMGFDIEASHHEVAPGQHEIDFKYADAVT
ACDNIQTFKLVVKTIARKHNLHATFMPKPLFGVNGSGMHFNVSLFKGKEN
AFFDPNTEMGLTETAYQFTAGVLKNARGFTAVCNPLVNSYKRLVPGYEAP
CYIAWSGKNRSPLIRVPSSRGLSTRIEVRSVDPAANPYMALAAILEAGLD
GIKNKLKVPEPVNQNIYEMNREEREAVGIQDLPSTLYTALKAMRENEVIK
KALGNHIYNQFINSKSIEWDYYRTQVSEWERDQYMKQY

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7tf6 Chain N Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7tf6 Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria.
• Resolution: 2.15 Å
• Binding residue (original residue number in PDB): E134 H247 E335
• Binding residue (residue number reindexed from 1): E126 H239 E327
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 6.3.1.2: glutamine synthetase.

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004356 glutamine synthetase activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006542 glutamine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7tf6, PDBe:7tf6, PDBj:7tf6
• PDBsum: 7tf6
• PubMed: 35778410
• UniProt: E3VXC2