Structure of PDB 7ojn Chain L Binding Site BS05

Receptor Information
>7ojn Chain L (length=2010) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEDDMACVKDLVSKYLADNERLSRQKLAFLVQTEPRMLLMEGLKLLSLCI
EIDSCNANGCEHNSEDKSVERILHDHGILTPSLCFVVPDGYKLTGNVLIL
LECFVRSSPANFEQKYIEDFKKLEQLKEDLKSVDINLIPLIDGRTSFYNE
QIPDWVNDKLRDTLFSLLRYAQESNSLFEESEYSRLCESLSMTSGRLSGV
ESLNVLLDNRSSHYEEIIASCHQGINNKLTAHEVKLQIEEEYQVFRNRLR
KGEITGQFLKVDKSRLLNDFNNLYVDEVTATKDNIEHLIYQFKRASPILR
FLYANIGHHTIKECQMQYWRSFLNKVKSLRILNTRRKLLLIFDALILLAS
IHDQTRHKCSKGWLGSCFISVNDRLVSLESTKRDLEKWVGRRQQSERPPD
KNQILISMFQKTILKATAALKDVGISVEHYKINMEVICPDSYDLILNFDV
SGVVPTISYQRTEDEKFPFIMGGVELLESTDLERLSSLSLALVNSMKTSS
TVKLRQNEFGPARYQVVRCKEAYCQEFLLSGAEFQLIYQKTGECSKCYAI
NDNRVGEICSFYADPKRYFPAIFSAEVLQTTVSTMISWVKDCSELEEQLC
NINSLTKMILVLILAHPSKRSQKLLQNLRYFIMAYVSDYHHKDLIDKLRE
ELITDVEFLLYRLVRALVNLILSEDVKSMMTNRFKFILNISYMCHFITKE
TPDRLTDQIKCFEKFLEPKLEFGHVSINPADVATEEELDDMVYNAKKFLS
KEGCTSIKGPDYKKPGVSKRFLSLLTSSFNNGSLFKESEVKREIKDPLVT
SGCATALDLASNKSVVVNKYTDGSRVLNYDFNKLTALAVSQLTEVFSRKG
KDYDYKVQQAMSNLYFDQLKETVERIIDQYDMGRLSDDVRISERESNSEA
LSKALSLTNCTTAMLKNLCFYSQESPQSYSSTGPDTGRLKFSLSYKEQVG
GNRELYIGDLRTKMFTRLIEDYFEALSLQLSGSCLNNEREFENAILSMKL
NVSLAHVSYSMDHSKWGPMMCPFLFLATLQNLIFLSKDLQADIKGRDYLS
TLLTWHMHKMVEIPFNVVSAMMKSFIKAQLGLKKKTTQSITEDFFYSNFQ
IGVVPSHVSSILDMGQGILHNTSDFYALISERFINYAISCICGGTIDAYT
SSDDQISLFDQVLTELMQRDPEEFKTLIEFHYYMSDQLNKFVSPKSVIGR
FVAEFKSRFYVWGDEVPLLTKFVAAALHNIKCKEPHQLAETIDTIIDQSV
ANGVPVHLCNLIQKRTLSLLQYARYPIDPFLLNCETDVRDWVDGNRSYRI
MRQIERLIPDACGRIRSMLRKLYNKLKTGQLHEEFTTNYLSSEHLSSLSN
LCELLGVEPPSESDLEFSWLNLAAHHPLRMVLRQVPTIVKTIQNKLSSTF
TRGAQKLLSEAINKSAFQSSIASGFVGLCRTLGSKCVRGPNKESLYIKSI
QSLISDIQGIEPLIDSHGVQYWRVPLNIRDGNEGVISYFRPLLWDYMCIS
LSTAIELGAWVLGEPKKVRVLEFFKHNPCDYFPLKPAASKLLEDRVGLNH
IIHSLRRLYPSVFEKHILPFMSDLASTKMKWSPRIKFLDLCVALDVNCEA
LSLVSHIVKWKREEHYIVLSSELRLSHTRTHEVVSTSDAVDNFMRQIYFE
SYVRSFVATTRTLGSFTWFPHKTSVPEGEGLQRLGPFSSFVEKAIHKGIE
RPMFKHDLMMGYAWIDFDIEPARFNHNQLIASGLVGPRFDSLEDFFDAVE
SLPPGSAKLSQTVRFRIKSQDASFKESFAIHLDYTGSINQQTKYLVHEVS
AMYSGAVSPCVLSDCWRLVLSGPTFKGKSAWYVDTEIVNEFLTDTNQLGH
VTPVEIVVDMEKLQFTEYDFVLVGPCVEPVPLVVHRGGLWECDKKLASFT
PVVQDQDLEMFVKEVGDSSLDLLIGALSAMILDRLKLRMQWSEVDIVSML
KAAMPSNSVKVLNAVLEAVDDWVDFKGYALCYSKSRKKVMVHSSGGKLRL
KGRTCEELVK
Ligand information
Ligand ID2KH
InChIInChI=1S/C9H16N3O14P3/c13-5-1-2-12(9(16)10-5)8-7(15)6(14)4(25-8)3-24-27(17,18)11-28(19,20)26-29(21,22)23/h1-2,4,6-8,14-15H,3H2,(H,10,13,16)(H2,21,22,23)(H3,11,17,18,19,20)/t4-,6-,7-,8-/m1/s1
InChIKeyOZIBFYOFLVBDIY-XVFCMESISA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(NP(=O)(O)OP(=O)(O)O)O)O)O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)NP(=O)(O)OCC2OC(N1C(=O)NC(=O)C=C1)C(O)C2O
CACTVS 3.385O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(=O)N[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
CACTVS 3.385O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P](O)(=O)N[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.7.6C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(NP(=O)(O)OP(=O)(O)O)O)O)O
FormulaC9 H16 N3 O14 P3
Name5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine
ChEMBL
DrugBank
ZINCZINC000098208190
PDB chain7ojn Chain L Residue 2301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ojn Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity.
Resolution2.92 Å
Binding residue
(original residue number in PDB)		K1124 R1131 D1190 H1191 K1193 W1194 G1195 Q1294 G1295 D1331
Binding residue
(residue number reindexed from 1)		K946 R953 D1012 H1013 K1015 W1016 G1017 Q1116 G1117 D1153
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ojn, PDBe:7ojn, PDBj:7ojn
PDBsum7ojn
PubMed34857749
UniProtA0A3S8NV63

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