Structure of PDB 6sh8 Chain K Binding Site BS05

Receptor Information

>6sh8 Chain K (length=1024) Species: 930945 (Sulfolobus islandicus REY15A)

EFLDYKIIALLHDPPNKAWVITGRARNLTQQLSRKHEKVAKYIINQLFGK
NYSEKVDNADKLASSIDRYLGSIVYKERSLFENRSIFLKNILLSNIQRDI
GNLFPKDKSKLDNLILEYKKLLNVINKTNLILKYQLFYLIYELVWIDSKY
ENTPSDTRNPTHTIFDHLYATAAMMNWILSLEKEAKGYLLGIDTIGVADF
ISKGRKTRDLWISSYLVSALLWYVITWFIEEYGPDVILFPSLRFNQFYAF
YLLEKLRKEGVSEDVIDEIKELITKYIFNGDDLFENLKIPPYPIIPGRIT
LILPGLIREGEEYKKVQDDNCFISKVKERYNEGWRKLIEGLRCYSERKRE
DGFWNLVCRVLKLTEDLLQTTPLNIRVKQVSVTEDEIFNNNKLRSDSWKI
YDNKYRQLVSEFKKSKLVKVTPESRLKLFELTKFDKLPQIGEKSKRGYEF
CTSCGVLPAVVIMPKEDELEKKLIDLGIARDEKDVRSIKNMISPGERLCP
WCLVKRALGAEPRLMRILLLGDLYSVEKIVNEIVSRDVKIEIPSTSDIAS
IKTFEEMIEKKNEICEDLKEEEVCEKPSESVLSMWQWFNKNYYNGINLTI
DPEEYWFSEKRRRYYFSVFRRHRITFPSPYYALVRADSDYLGDLLEGKLT
PYLAGIIDSGDYANISEKKEEVNKLLEEYLVNAGSGSIVDYVKTVLKCIR
ENLNKCSCAEKIYSNEVAKVMFRVNVEKANVEEEVKNSLEYFETILNEGR
IIVTPAWHVSISSALNRGLLVELELVNKHKGFVIYAGGDDLLAMLPVDEV
LDFIKESRRAFAGFGTEKLGNMCLENGFVRINNAYYPSLPIVGRSYSVII
AHYADPLFFVINDSYNLLEEGKEIIRYRVMYNGEYKDAKKDVAIFRYQGL
TSVIPLSLKRPIVSSVSDFNEIASIIDVILELKKRIDEGRISVSLLYDYE
KYKHLIVASDEKYLTEFLVKDWIKRNSLRKHVEFTIDEKLYGVRLTIENY
PIKIPNDLISNIVYTLRIIYGGEK

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 6sh8 Chain K Residue 1104

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6sh8 Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas.
• Resolution: 3.14 Å
• Binding residue (original residue number in PDB): D650 S651
• Binding residue (residue number reindexed from 1): D637 S638
• Annotation score: 4

Gene Ontology

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6sh8, PDBe:6sh8, PDBj:6sh8
• PDBsum: 6sh8
• PubMed: 32730741
• UniProt: F0NDX2