Structure of PDB 8fak Chain H Binding Site BS05

Receptor Information
>8fak Chain H (length=643) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PVAHVALPVPLPRTFDYLLPEGMTVKAGCRVRVPFGKQQERIGIVVSVSD
ASELPLNELKAVVEVLDSEPVFTHSVWRLLLWAADYYHHPIGDVLFHALP
ILLRQGRPAANTEQATAVGAIHSAADTFSAWLLAGVTGSGKTEVYLSVLE
NVLAQGKQALVMVPEIGLTPQTIARFRERFNAPVEVLHSGLNDSERLSAW
LKAKNGEAAIVIGTRSALFTPFKNLGVIVIDEEHDSSYKQQEGWRYHARD
LAVYRAHSEQIPIILGSATPALETLCNVQQKKYRLLRLTRRAGNARPAIQ
HVLDLKGQKVQAGLAPALITRMRQHLQADNQVILFLNRRGFAPALLCHDC
GWIAECPRCDHYYTLHQAQHHLRCHHCDSQRPVPRQCPSCGSTHLVPVGL
GTEQLEQTLAPLFPGVPISRIDRDTTSRKGALEQQLAEVHRGGARILIGT
QMLAKGHHFPDVTLVALLDVDGALFSADFRSAERFAQLYTQVAGRAGRAG
KQGEVVLQTHHPEHPLLQTLLYKGYDAFAEQALAERRMMQLPPWTSHVIV
RAEDHNNQHAPLFLQQLRNLILSSPLADEKLWVLGPVPALAPKRGGRWRW
QILLQHPSRVRLQHIINGTLALINTIPDSRKVKWVLDVDPIEG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8fak Chain H Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8fak Replication fork binding triggers structural changes in the PriA helicase that govern DNA replication restart in E. coli.
Resolution3.22 Å
Binding residue
(original residue number in PDB)		C436 C476
Binding residue
(residue number reindexed from 1)		C347 C387
Annotation score4
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0043138 3'-5' DNA helicase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006269 DNA replication, synthesis of primer
GO:0006270 DNA replication initiation
GO:0006276 plasmid maintenance
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0010332 response to gamma radiation
GO:0031297 replication fork processing
GO:0032508 DNA duplex unwinding
GO:0046677 response to antibiotic
Cellular Component
GO:1990077 primosome complex
GO:1990158 DnaB-DnaC-DnaT-PriA-PriB complex
GO:1990159 DnaB-DnaC-DnaT-PriA-PriC complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8fak, PDBe:8fak, PDBj:8fak
PDBsum8fak
PubMed37169801
UniProtP17888|PRIA_ECOLI Primosomal protein N' (Gene Name=priA)

[Back to BioLiP]