Structure of PDB 7ug7 Chain EF Binding Site BS05

Receptor Information
>7ug7 Chain EF (length=672) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTPIARYRNIGISAHIDAGKTTTTERILFYTGVNHKSAATTAFWSGMAKQ
YEPHRINIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWR
QANKYKVPRIAFVNKMDRMGANFLKVVNQIKTRLGANPVPLQLAIGAEEH
FTGVVDLVKMKAINWNDADQGVTFEYEDIPADMVELANEWHQNLIESAAE
ASEELMEKYLGGEELTEAEIKGALRQRVLNNEIILVTCGSAFKNKGVQAM
LDAVIDYLPSPVDVPAINGILDDGKDTPAERHASDDEPFSALAFKIATDP
FVGNLTFFRVYSGVVNSGDTVLNSVKAARERFGRIVQMHANKREEIKEVR
AGDIAAAIGLKDVTTGDTLCDPDAPIILERMEFPEPVISIAVEPKTKADQ
EKMGLALGRLAKEDPSFRVWTDEESNQTIIAGMGELHLDIIVDRMKREFN
VEANVGKPQVAYRETIRQKVTDVEGKHAKQSGGRGQYGHVVIDMYPLEPG
SNPKGYEFINDIKGGVIPGEYIPAVDKGIQEQLKAGPLAGYPVVDMGIRL
HFGSYHDVDSSELAFKLAASIAFKEGFKKAKPVLLEPIMKVEVETPEENT
GDVIGDLSRRRGMLKGQESEVTGVKIHAEVPLSEMFGYATQLRSLTKGRA
SYTMEFLKYDEAPSNVAQAVIE
Ligand information
Receptor-Ligand Complex Structure
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PDB7ug7 The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation.
Resolution2.58 Å
Binding residue
(original residue number in PDB)		E413 P414 I416 S417 W448 D450 P486 Q487 V488 A489 L660 M682 F684
Binding residue
(residue number reindexed from 1)		E385 P386 I388 S389 W420 D422 P458 Q459 V460 A461 L632 M654 F656
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0032790 ribosome disassembly
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ug7, PDBe:7ug7, PDBj:7ug7
PDBsum7ug7
PubMed35500116
UniProtP0A6M8|EFG_ECOLI Elongation factor G (Gene Name=fusA)

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