Structure of PDB 5ak9 Chain E Binding Site BS05

Receptor Information
>5ak9 Chain E (length=183) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ENVSGISAYLLGLIIGDGGLYKLKYKGNRSEYRVVITAKSENLIKQHIAP
LMQFLIDELNVKSKIQIVKGDTRYELRVSSKKLYYYFANMLERIRLFNMR
EQIAFIKGLYVAEGDMTLKRLRIWNKNKALLEIVSRWLNNLGVRNTIHLD
DHRHGVYVLNISLRDRIKFVHTILSSHLNPLPP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5ak9 Engineering a Nickase on the Homing Endonuclease I-Dmoi Scaffold.
Resolution2.601 Å
Binding residue
(original residue number in PDB)		N32 R33 S34 E35 Y36 R37 S67 K68 Q70 R81 S83 S84 K85 E117 G118 D119 R126 W128 K130 D155 H158
Binding residue
(residue number reindexed from 1)		N28 R29 S30 E31 Y32 R33 S63 K64 Q66 R77 S79 S80 K81 E113 G114 D115 R122 W124 K126 D151 H154
Binding affinityPDBbind-CN: Kd=0.3nM
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
Biological Process
GO:0006314 intron homing
GO:0016539 intein-mediated protein splicing

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Molecular Function
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Biological Process
External links
PDB RCSB:5ak9, PDBe:5ak9, PDBj:5ak9
PDBsum5ak9
PubMed26045557
UniProtP21505|DMO1_DESMO Homing endonuclease I-DmoI

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