Structure of PDB 4n0o Chain E Binding Site BS05

Receptor Information

>4n0o Chain E (length=396) Species: 299386 (Equine arteritis virus Bucyrus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

AVCTVCGAAPVAKSACGGWFCGNCVPYHAGHCHTTSLFACGHDIMYRSTY
CTMCEGSPKQMVPKVPHPILDHLLCHIDYGSKEELTLVVADGTTSPPGRY
KVGHKVVAVVADVGGNIVFGCPGSHIVPLQDTLKGVVVNKALKNAAASEY
VEGPPGSGKTFHLVKDVLAVVGSATLVVPTHASMLDCINKLKQAGADPYF
VVPKYTVLDFPRPGSGNITVRLPQVGTSEGETFVDEVAYFSPVDLARILT
QGRVKGYGDLNQLGCVGPASVPRNLWLRHFVSLEPLRVCHRFGAAVCDLI
KGIYPYYEPAPHTTKVVFVPNPDFEKGVVITAYHKDRGLGHRTIDSIQGC
TFPVVTLRLPTPQSLTRPRAVVAVTRASQELYIYDPFDQLSGLLKF

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

4n0o Chain E Residue 505 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4n0o Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase.
Resolution	2.65 Å
Binding residue (original residue number in PDB)	A2 V3
Binding residue (residue number reindexed from 1)	A1 V2
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.7.7.48: RNA-directed RNA polymerase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.21.-
3.4.22.-
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-

Gene Ontology

	Molecular Function
GO:0005524	ATP binding
GO:0008270	zinc ion binding

View graph for
Molecular Function

External links

PDB	RCSB:4n0o, PDBe:4n0o, PDBj:4n0o
PDBsum	4n0o
PubMed	24369429
UniProt	P19811\|RPOA_EAVBU Replicase polyprotein 1ab (Gene Name=rep)

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