Structure of PDB 8wwv Chain D Binding Site BS05

Receptor Information

>8wwv Chain D (length=490) Species: 1615674 (Pseudomonas lactis)

DFITKNNLWTNEQRDAADKVLAEIDSLGLEMIRLSWADQYGLLRGKSLTV
ASLKSAFKEGSEVAIGPFFFDLVSSMVFNLFTTAGDFEDELSGNPTVVMV
PDPTTFKVLPWADKTGWMLADLHWKSGEPFPLCPRGIMKKAVKSLSDEGY
LFKCGIELEWYLTKIVDRSLSPESLGAPGVQPDAIQVQPVAQGYSVLLEH
HLDQVDDIMSKVRKGLLELNLPLRSIEDEWAPSQMETTFDVMEGLEAADA
ALLIKSAIKQICSRHGYHATFMCKPAINGFFASGWHMHQSLVDKDTRKNL
FIPSEGEVLSPLGRAYAGGLLANGSAASSFTTPTVNGYRRRQPYSLAPDR
RAWAKDNKAAMVRVVSATGDPASRIENRIGEPGANPYLYMASQIVSGLDG
IKNKKDPGELQESPYDAQVPMLPTTLAEALDALEHDSELFRSCFGDTFIK
YWLQLRRSEWARFLDAEGAEAAEPTGAVTQWEQKEYFNLL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8wwv Chain D Residue 505

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8wwv Discovery of the 1-naphthylamine biodegradation pathway reveals a glutamine synthetase-like protein that catalyzes 1-naphthylamine glutamylation
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): E162 E241
• Binding residue (residue number reindexed from 1): E157 E236
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 6.3.1.2: glutamine synthetase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003824 catalytic activity
• GO:0004356 glutamine synthetase activity
• GO:0016879 ligase activity, forming carbon-nitrogen bonds
• GO:0046872 metal ion binding

Biological Process

• GO:0006542 glutamine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0016020 membrane

External links

• PDB: RCSB:8wwv, PDBe:8wwv, PDBj:8wwv
• PDBsum: 8wwv
• UniProt: A0A7Y1Q2L1