Structure of PDB 8gvx Chain D Binding Site BS05

Receptor Information
>8gvx Chain D (length=686) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCM
DPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLL
SYRRPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRV
TIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDP
ILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELE
IILNHRDDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWV
VKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFL
FMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFT
EYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIA
EALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVL
LAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWS
VFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSY
QLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSLIQNQHYQEVIR
NLVKRYVAAMIRNTEENFKELKQDISSFRYEVLDLL
Ligand information
Ligand IDYZY
InChIInChI=1S/C37H70O5/c1-3-5-7-9-11-13-15-17-18-20-21-23-25-27-29-31-36(39)41-34-35(33-38)42-37(40)32-30-28-26-24-22-19-16-14-12-10-8-6-4-2/h17-18,35,38H,3-16,19-34H2,1-2H3/b18-17-/t35-/m0/s1
InChIKeyDOZKMFVMCATMEH-OZKTZCCCSA-N
SMILES
SoftwareSMILES
CACTVS 3.370CCCCCCCCCCCCCCCC(=O)O[C@@H](CO)COC(=O)CCCCCCC\C=C/CCCCCCCC
OpenEye OEToolkits 1.7.6CCCCCCCCCCCCCCCC(=O)OC(CO)COC(=O)CCCCCCCC=CCCCCCCCC
OpenEye OEToolkits 1.7.6CCCCCCCCCCCCCCCC(=O)O[C@@H](CO)COC(=O)CCCCCCC/C=C\CCCCCCCC
ACDLabs 12.01O=C(OC(CO)COC(=O)CCCCCCC\C=C/CCCCCCCC)CCCCCCCCCCCCCCC
CACTVS 3.370CCCCCCCCCCCCCCCC(=O)O[CH](CO)COC(=O)CCCCCCCC=CCCCCCCCC
FormulaC37 H70 O5
Name(2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate
ChEMBL
DrugBank
ZINCZINC000040164793
PDB chain8gvx Chain D Residue 805 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8gvx Molecular architecture of the G alpha i -bound TRPC5 ion channel.
Resolution3.91 Å
Binding residue
(original residue number in PDB)		L514 L521 Y524 Q573 F576
Binding residue
(residue number reindexed from 1)		L486 L493 Y496 Q545 F548
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005262 calcium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gvx, PDBe:8gvx, PDBj:8gvx
PDBsum8gvx
PubMed37137991
UniProtQ9UL62|TRPC5_HUMAN Short transient receptor potential channel 5 (Gene Name=TRPC5)

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