Structure of PDB 3erc Chain D Binding Site BS05

Receptor Information

>3erc Chain D (length=445) Species: 10254 (Vaccinia virus WR)

NITLKIIETYLGRVPSVNEYHMLKSQARNIQKITVFNKDIFVSLVKKNKK
RFFSDVNTSASEIKDRILSYFSKQTQTYNIGKLFTIIELQSVLVTTYTDI
LGVLTINVTSMEELARDMLNSMNVAVVSSLVKNVNKLMEEYLRRHNKSCI
CYGSYSLYLINPNIRYGDIDILQTNSRTFLIDLAFLIKFITGNNIILSKI
PYLRNYMVIKDENDNHIIDSFNIRQDTMNVVPKIFIDNIYIVDPTFQLLN
MIKMFSQIDRLEDLSKDPEKFNARMATMLEYVRYTHGIVFDGKRNNMPMK
CIIDENNRIVTVTTKDYFSFKKCLVYLDENVLSSDILDLNADTSCDFESV
TNSVYLIHDNIMYTYFSNTILLSDKGKVHEISARGLCAHILLYQMLTSGE
YKQCLSDLLNSMMNRDKIPIYSHTERDKKPGRHGFINIEKDIIVF

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 3erc Chain D Residue 903

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3erc Polymerase Translocation with Respect to Single-Stranded Nucleic Acid: Looping or Wrapping of Primer around a Poly(A) Polymerase
• Resolution: 3.21 Å
• Binding residue (original residue number in PDB): D202 D204 D253
• Binding residue (residue number reindexed from 1): D168 D170 D219
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.19: polynucleotide adenylyltransferase.

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016740 transferase activity
• GO:0046872 metal ion binding
• GO:1990817 poly(A) RNA polymerase activity

Biological Process

• GO:0006397 mRNA processing

External links

• PDB: RCSB:3erc, PDBe:3erc, PDBj:3erc
• PDBsum: 3erc
• PubMed: 19446524
• UniProt: P23371|PAP1_VACCW Poly(A) polymerase catalytic subunit (Gene Name=OPG063)