Structure of PDB 4v63 Chain CX Binding Site BS05

Receptor Information

>4v63 Chain CX (length=354) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MLDKLDRLEEEYRELEALLSDPEVLKDKGRYQSLSRRYAEMGEVIGLIRE
YRKVLEDLEQAESLLDDPELKEMAKAEREALLARKEALEKELERHLLPKD
PMDERDAIVEIRAGTGGEEAALFARDLFNMYLRFAEEMGFETEVLDSHPT
DLGGFSKVVFEVRGPGAYGTFKYESGVHRVQRVPVTETQGRIHTSTATVA
VLPKAEEEDFALNMDEIRIDVMRASGPGGQGVNTTDSAVRVVHLPTGIMV
TCQDSRSQIKNREKALMILRSRLLEMKRAEEAERLRKTRLAQIGTGERSE
KIRTYNFPQSRVTDHRIGFTTHDLEGVLSGHLTPILEALKRADQERQLAA
LAEG

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

4v63 Chain CX Residue 408 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4v63 Structural basis for translation termination on the 70S ribosome
Resolution	3.207 Å
Binding residue (original residue number in PDB)	H193 T194
Binding residue (residue number reindexed from 1)	H193 T194
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003747	translation release factor activity
GO:0016149	translation release factor activity, codon specific

	Biological Process
GO:0006412	translation
GO:0006415	translational termination

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Cellular Component

External links

PDB	RCSB:4v63, PDBe:4v63, PDBj:4v63
PDBsum	4v63
PubMed	18596689
UniProt	Q72HB8\|RF1_THET2 Peptide chain release factor 1 (Gene Name=prfA)

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