Structure of PDB 8jq5 Chain C Binding Site BS05

Receptor Information

>8jq5 Chain C (length=413) Species: 47715 (Lacticaseibacillus rhamnosus)

MVKPEEVDKAYEVAKQRYAEIGVDTDAAMKELEKVPLSVHCWQGDDIHGF
LFPNQSGNYPGIARTPDELAGDMHEALSLIPGKHRVQLHAIYAVTDKKRD
LDTLEPEDFDYWIDWAKQEGVGLDFNGTFFSHPMVKDNMTVSSPDPKVRD
FWIRHGKISREISNYIGEKLGSQVVNNFWLPDGFKDNPIDKKTPRLRLLK
ALDEIIKDPLPEKNTIESFEGKLFGTGIESYTTGSHEFYQNYAISRNKLW
TIDAGHFHPTEDVSDKFSAFFPFGKGLFMHVSRPVRWDSDHVVIMDDALI
RITRSLVRDGYLDRTHIGLDFFDATINRVAAWVVGARATQKSLLQAMLAP
IDQLKKDELNADFTTRLIETEELKSFPFGAVWDKFCQDHNTPVGFDWMNN
IHQYEKDVQFKRD

Ligand information

• Ligand ID: PSV
• InChI: InChI=1S/C6H12O6/c7-1-3-4(9)5(10)6(11,2-8)12-3/h3-5,7-11H,1-2H2/t3-,4-,5-,6+/m1/s1
• InChIKey: RFSUNEUAIZKAJO-KAZBKCHUSA-N
• SMILES:
  OpenEye OEToolkits 1.7.0: C([C@@H]1[C@H]([C@H]([C@@](O1)(CO)O)O)O)O
  ACDLabs 11.02: OC1C(O)C(OC1(O)CO)CO
  CACTVS 3.352: OC[CH]1O[C](O)(CO)[CH](O)[CH]1O
  OpenEye OEToolkits 1.7.0: C(C1C(C(C(O1)(CO)O)O)O)O
  CACTVS 3.352: OC[C@H]1O[C@@](O)(CO)[C@H](O)[C@@H]1O
• Formula: C6 H12 O6
• Name: alpha-D-psicofuranose;
  alpha-D-psicose;
  D-psicose;
  psicose
• PDB chain: 8jq5 Chain C Residue 505

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8jq5 X-ray structure and characterization of a probiotic Lactobacillus rhamnosus Probio-M9 L-rhamnose isomerase.
• Resolution: 1.73 Å
• Binding residue (original residue number in PDB): K91 H92 R93 G130
• Binding residue (residue number reindexed from 1): K83 H84 R85 G122
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 5.3.1.14: L-rhamnose isomerase.

Gene Ontology

Molecular Function

• GO:0008740 L-rhamnose isomerase activity
• GO:0016853 isomerase activity
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0019299 rhamnose metabolic process
• GO:0019301 rhamnose catabolic process
• GO:0019324 L-lyxose metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:8jq5, PDBe:8jq5, PDBj:8jq5
• PDBsum: 8jq5
• PubMed: 38430263
• UniProt: A0A171J5T1