Structure of PDB 7jl3 Chain C Binding Site BS05

Receptor Information
>7jl3 Chain C (length=650) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPFKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQG
QKGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIV
ENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMF
NYLDQKLGGGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIA
TVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRIC
KDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPKDEESRICKALFLY
TSHLRKYNDALIISEHARMKDALDYLKDFFSNVEIEQDLTQRFEEKLQEL
ESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWI
EGNPKLSFLKPGILTGRGGMTLPAQKCILDAFKGDHNILIATSVADEGID
IAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINM
YKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQEKENKKLLCRK
CKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKKRAKIFCARQN
CSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7jl3 Chain C Residue 2004 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7jl3 Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		C810 C813 C864 C869
Binding residue
(residue number reindexed from 1)		C548 C551 C596 C601
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7jl3, PDBe:7jl3, PDBj:7jl3
PDBsum7jl3
PubMed33373584
UniProtO95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

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