Structure of PDB 7f05 Chain C Binding Site BS05

Receptor Information
>7f05 Chain C (length=355) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SEEGLNFPTYDGKDRVVSLSEKNFKQVLKKYDLLCLYYHEPVSSDKVTQK
QFQLKEIVLELVAQVLEHKAIGFVMVDAKKEAKLAKKLGFDEEGSLYILK
GDRTIEFDGEFAADVLVEFLLDLIEDPVEIISSKLEVQAFERIEDYIKLI
GFFKSEDSEYYKAFEEAAEHFQPYIKFFATFDKGVAKKLSLKMNEVDFYE
PFMDEPIAIPNKPYTEEELVEFVKEHQRPTLRRLRPEEMFETWEDDLNGI
HIVAFAEKSDPDGYEFLEILKQVARDNTDNPDLSILWIDPDDFPLLVAYW
EKTFKIDLFRPQIGVVNVTDADSVWMEIPDDDDLPTAEELEDWIEDVLSG
KINTE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7f05 Chain C Residue 406 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7f05 Ca2+-dependent Formation of a Non-transmembrane Channel in a Calsequestrin-2 Dimer
Resolution2.298 Å
Binding residue
(original residue number in PDB)		E184 E187
Binding residue
(residue number reindexed from 1)		E166 E169
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0048306 calcium-dependent protein binding
GO:0140314 calcium ion sequestering activity
Biological Process
GO:0002027 regulation of heart rate
GO:0005513 detection of calcium ion
GO:0006874 intracellular calcium ion homeostasis
GO:0006941 striated muscle contraction
GO:0010649 regulation of cell communication by electrical coupling
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0043267 negative regulation of potassium ion transport
GO:0051208 sequestering of calcium ion
GO:0051258 protein polymerization
GO:0060048 cardiac muscle contraction
GO:0060306 regulation of membrane repolarization
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0071313 cellular response to caffeine
GO:0086029 Purkinje myocyte to ventricular cardiac muscle cell signaling
GO:1901017 negative regulation of potassium ion transmembrane transporter activity
Cellular Component
GO:0005737 cytoplasm
GO:0014701 junctional sarcoplasmic reticulum membrane
GO:0016529 sarcoplasmic reticulum
GO:0030018 Z disc
GO:0033017 sarcoplasmic reticulum membrane
GO:0033018 sarcoplasmic reticulum lumen
GO:0034704 calcium channel complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7f05, PDBe:7f05, PDBj:7f05
PDBsum7f05
PubMed
UniProtO14958|CASQ2_HUMAN Calsequestrin-2 (Gene Name=CASQ2)

[Back to BioLiP]