Structure of PDB 7dxe Chain C Binding Site BS05

Receptor Information
>7dxe Chain C (length=685) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVG
NEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRL
TLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKG
ARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSED
PVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEV
EAILNGDSLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIA
IKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFL
GLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLG
MMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKA
QQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVV
LSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFI
LYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIG
YVLYGIYNVTMVVVLLNMLIAMINSSYDDSDVEWKFARSKLWLSYFDKTL
PPPFSLVPQPTRYQQIMKRLIKRYVLKAQVDKEND
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7dxe Chain C Residue 904 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7dxe Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H178 C182 C184 C187
Binding residue
(residue number reindexed from 1)		H157 C161 C163 C166
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005227 calcium-activated cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0015279 store-operated calcium channel activity
GO:0046872 metal ion binding
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0007338 single fertilization
GO:0007602 phototransduction
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0033198 response to ATP
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051592 response to calcium ion
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034703 cation channel complex

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7dxe, PDBe:7dxe, PDBj:7dxe
PDBsum7dxe
PubMed35051376
UniProtQ13507|TRPC3_HUMAN Short transient receptor potential channel 3 (Gene Name=TRPC3)

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