Structure of PDB 6wb7 Chain C Binding Site BS05

Receptor Information
>6wb7 Chain C (length=293) Species: 134676 (Actinoplanes sp. SE50/110) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HTDVLVLGGAGVDTIAYVPELPLPFQDSYVVAAIEPRAGQTGDNVALGLH
TLGLRTMHVDVLGDDPEGDLVRAFHTRHGLPFAALPTAAGTKRAVNLVGP
DGRRLSLWDGSREAEEDRYPAALIAAHTAHARHVHVCITPPGQHVFGQLN
DLPVTVSTDLHNWDGAYEGFEVYAFNADLVFLSATALTDVAATMRRVIDR
GRARLVVATDGAHGGSVLVRGETEVRRYAAVAPEAPVVDSNGAGDAFVSG
FLFGHLAGEPLETCLRYGAIAGAYACTIPATRAGAIDRAALLR
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain6wb7 Chain C Residue 305 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6wb7 The human microbiome encodes resistance to the antidiabetic drug acarbose.
Resolution2.44 Å
Binding residue
(original residue number in PDB)		D202 G204
Binding residue
(residue number reindexed from 1)		D199 G201
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.1.187: acarbose 7(IV)-phosphotransferase.
Gene Ontology
Molecular Function
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0016310 phosphorylation
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wb7, PDBe:6wb7, PDBj:6wb7
PDBsum6wb7
PubMed34819672
UniProtQ8RMD4|ACBK_ACTS5 Acarbose 7(IV)-phosphotransferase (Gene Name=acbK)

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