Structure of PDB 6jlh Chain C Binding Site BS05

Receptor Information
>6jlh Chain C (length=256) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GFLQIWQHFDADDNGYIEGKELDDFFRHMLKKLQPKDKITDERVQQIKKS
FMSAYDATFDGRLQIEELANMILPQEENFLLIFRREAPLDNSVEFMKIWR
KYDADSSGYISAAELKNFLKDLFLQHKKKIPPNKLDEYTDAMMKIFDKNK
DGRLDLNDLARILALQENFLLQFKMDASSQVERKRDFEKIFAHYDVSRTG
ALEGPEVDGFVKDMMELVRPSISGGDLDKFRECLLTHCDMNKDGKIQKSE
LALCLG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6jlh Chain C Residue 304 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6jlh Structural and mechanistic insights into secretagogin-mediated exocytosis.
Resolution2.37 Å
Binding residue
(original residue number in PDB)		D114 D116 S118 Y120 E125
Binding residue
(residue number reindexed from 1)		D103 D105 S107 Y109 E114
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0007420 brain development
GO:0021522 spinal cord motor neuron differentiation
GO:0099509 regulation of presynaptic cytosolic calcium ion concentration
GO:1900271 regulation of long-term synaptic potentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030425 dendrite
GO:0043195 terminal bouton
GO:0045202 synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6jlh, PDBe:6jlh, PDBj:6jlh
PDBsum6jlh
PubMed32156735
UniProtQ5XJX1|SEGN_DANRE Secretagogin (Gene Name=scgn)

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