Structure of PDB 5n6n Chain C Binding Site BS05

Receptor Information
>5n6n Chain C (length=698) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPFSNAEVYYGNRTRTMSVFDNVSPFKKTGFGKLQQTRRGSEDDTYSSSQ
GNRRFFIEDVDKTLNELLAAEDTDKNYQITIEDTGPKVLKVGTANSYGYK
HINIRGTYMLSNLLQELTIAKSFGRHQIFLDEARINENPVNRLSRLINTQ
FWNSLTRRVDLNNVGEIAKDTKIDTPGAKNPRIYVPYDCPEQYEFYVQAS
QMHPSLKLEVEYLPKKITAEYVKSVNDTPGLLALAMEEHFNPSTGEKTLI
GYPYAVPGGRFNELYGWDSYMMALGLLEANKTDVARGMVEHFIFEINHYG
KILNANRSYYLCRSQPPFLTEMALVVFKKLGGRSNPDAVDLLKRAFQASI
KEYKTVWTASPRLDPETGLSRYHPNGLGIPPETESDHFDTVLLPFKQLYN
DGKIKEPKLDEFFLHDRGVRESGHDTTYRFEGVCAYLATIDLNSLLYKYE
IDIADFIKEFCDDKYEDPLDHSITTSAMWKEMAKIRQEKITKYMWDDESG
FFFDYNTKIKHRTSYESATTFWALWAGLATKEQAQKMVEKALPKLEMLGG
LAACTERSRGPISISRPIRQWDYPFGWAPHQILAWEGLRSYGYLTVTNRL
AYRWLFMMTKAFVDYNGIVVEKYDVTRGTDPHRVEAEYGNQGADFKGAAT
EGFGWVNASYILGLKYMNSHARRALGACIPPISFFSSLRPQERNLYGL
Ligand information
Ligand IDGLC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-DVKNGEFBSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-glucopyranose;
alpha-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL423707
DrugBank
ZINCZINC000003861213
PDB chain5n6n Chain F Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5n6n Molecular basis of the 14-3-3 protein-dependent activation of yeast neutral trehalase Nth1.
Resolution2.29 Å
Binding residue
(original residue number in PDB)		Q540 A582 T583 K584
Binding residue
(residue number reindexed from 1)		Q487 A529 T530 K531
Annotation score5
Enzymatic activity
Enzyme Commision number 3.2.1.28: alpha,alpha-trehalase.
Gene Ontology
Molecular Function
GO:0004555 alpha,alpha-trehalase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0015927 trehalase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005991 trehalose metabolic process
GO:0005993 trehalose catabolic process
GO:0071465 cellular response to desiccation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5n6n, PDBe:5n6n, PDBj:5n6n
PDBsum5n6n
PubMed29087344
UniProtP32356|TREA_YEAST Cytosolic neutral trehalase (Gene Name=NTH1)

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