Structure of PDB 2ffl Chain C Binding Site BS05

Receptor Information
>2ffl Chain C (length=718) Species: 5741 (Giardia intestinalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AMHALGHCCTVVTTRGPSHWLLLLDTHLGTLPGFKVSAGRGLPAAEVYFE
AGPRVSLSRTDATIVAVYQSILFQLLGPTFPASWTEIGATMPHNEYTFPR
FISNPPQFATLAFLPLLSPTSPLDLRALMVTAQLMCDAKRLSDELSASLH
GRMVATPEISWSLYVVLGIDSTQTSLSYFTRANESITYMRYYATAHNIHL
RAADLPLVAAVRLDDLKDHQIPAPDDLAPKLRFLPPELCLLLPDEFDLIR
VQALQFLPEIAKHICDIQNTICALDKSFPDCGRIGGERYFAITAGLRLDQ
GRGRGLAGWRTPFGPFGVSHTDVFQRLELLGDAVLGFIVTARLLCLFPDA
SVGTLVELKMELVRNEALNYLVQTLGLPQLAEFSKSKTWADMYEEIVGSI
FTGPNGIYGCEEFLAKTLMSPEHSKTACPDAVTKASKRVCMGEAGAHEFR
SLVDYACEQGISVFCSSRVSTMFLERLRDIPAEDMLDWYRLGIQFSHRSG
LSVSVIDIMTHLARGLWLGSPGFYVEQPPTIPVLYIYHRSVQCPVLYGSL
TTGPVASKVLALYEKILASGGSKHIAAQTVSRSLAVPIPSGTIPFLIRLL
QIALTPHVYQKLELLGDAFLKCSLALHLHALHPTLTEGALTRMRQSAETN
SVLGRLTKRFPSVVSEVIIESHPKIQPDSKVYGDTFEAILAAILLACGEE
AAGAFVREHVLPQVVADA
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain2ffl Chain C Residue 5019 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2ffl Structural Basis of Double-Stranded RNA Processing by Dicer
Resolution3.33 Å
Binding residue
(original residue number in PDB)		E491 D495
Binding residue
(residue number reindexed from 1)		E475 D479
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004525 ribonuclease III activity
GO:0046872 metal ion binding
Biological Process
GO:0006396 RNA processing
GO:0031047 regulatory ncRNA-mediated gene silencing

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:2ffl, PDBe:2ffl, PDBj:2ffl
PDBsum2ffl
PubMed16410517
UniProtA8BQJ3|DCL_GIAIC Endoribonuclease Dicer-like (Gene Name=GL50803_103887)

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