Structure of PDB 8wcn Chain B Binding Site BS05

Receptor Information

>8wcn Chain B (length=378) Species: 287 (Pseudomonas aeruginosa)

NPYARQLRNGFRWLRFEKELENEFREFLSWNSLMQRRAAIGVAFLIWALF
IVADWMMVDIRLHPSLFEQLLGVRLGMIGLLLVVWPAAFLPSLRKVGDAI
APYCLLLINLAVLACDVLFEWHGVPRFTQLGATLGILAVFFPLGLAFWAC
VRLALLCLALNLAVFLLFGGEENLRTNLLNTLYNGLVVLICSFALYLQDY
AQREQFLGRRLLGMMAEQDSLTGLVNRRYYELLAQRALEQGAREEKGVAL
ILVDVDDFKAYNDHYGHPAGDAALRQLGVVLRQGARRPLDIAARLGGEEF
AVLLYDSEEGNTLAIAERLRQAVEALGIEHLGSSAGPCLTISLGVAYSTS
GMGLDALYREADRALYEAKDAGRNAVRV

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8wcn Chain B Residue 503

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8wcn A c-di-GMP signaling module controls responses to iron in Pseudomonas aeruginosa.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): D268 V269 E312
• Binding residue (residue number reindexed from 1): D254 V255 E298
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.65: diguanylate cyclase.

Gene Ontology

Molecular Function

• GO:0016779 nucleotidyltransferase activity
• GO:0052621 diguanylate cyclase activity

Biological Process

• GO:0043709 cell adhesion involved in single-species biofilm formation
• GO:1902201 negative regulation of bacterial-type flagellum-dependent cell motility

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8wcn, PDBe:8wcn, PDBj:8wcn
• PDBsum: 8wcn
• PubMed: 38424057
• UniProt: A0A072ZHL9