Structure of PDB 8jxe Chain B Binding Site BS05

Receptor Information
>8jxe Chain B (length=1468) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QPFHCPSTQWQCPGYSTCINLSALCDGVFDCPNGTDESPLCNQDSCSHFN
GGCTHQCMQGPFGATCLCPLGYQLANDTKTCEDINECDIPGFCSQHCVNM
RGSFRCACDPEYTLESDGRTCKVTGSENPLLVVASRDKIIVDNITAHTHN
LYSLVQDVSFVVALDFDSVTGRVFWSDLLQGKTWSVFQNGTDKRVVHDSG
LSVTEMIAVDWIGRNLYWTDYALETIEVSKIDGSHRTVLISKNVTKPRGL
ALDPRMGDNVMFWSDWGHHPRIERASMDGTMRTVIVQEKIYWPCGLSIDY
PNRLIYFMDAYLDYIEFCDYDGHNRRQVIASDLVLHHPHALTLFEDFVYW
TDRGTRQVMQANKWHGGNQSVVMYSVHQPLGITAIHPSRQPPSRNPCASA
SCSHLCLLSAQAPRHYSCACPSGWNLSDDSVNCVRGDQPFLMSVRDNIIF
GISLDPEVKSNDAMVPISGIQHGYDVEFDDSEQFIYWVENPGEIHRVKTD
GSNRTVFAPLSLLGSSLGLALDWVSRNIYYTTPASRSIEVLTLKGDTRYG
KTLIANDGTPLGVGFPVGIAVDPARGKLYWSDHGTDSGVPAKIASANMDG
TSLKILFTGNLQHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGTERMILV
HHLAHPWGLVVYGSFLYYSDEQYEVIERVDKSSGNNKVVLRDNVPYLRGL
RVYHRRNAADSSNGCSNNPNACQQICLPVPGGMFSCACASGFKLSPDGRS
CSPYNSFMVVSMLPAVRGFSLELSDHSEAMVPVAGQGRNVLHADVDVANG
FIYWCDFSSSVRSSNGIRRIKPDGSNFTNVVTYGIGANGIRGVALDWAAG
NLYFTNAFVYETLIEVLRINTTYRRVLLKVSVDMPRHIIVDPKHRYLFWA
DYGQKPKIERSFLDCTNRTVLVSEGIVTPRGLAMDHDTGYIYWVDDSLDL
IARIHLDGGESQVVRYGSRYPTPYGITVFGESIIWVDRNLKKVFQASKQP
GNTDPPVVIRDKINLLRDVTIFDEHAQPLSPAELNNNPCLQSNGGCSHFC
FALPELPTPRCGCAFGTLGNDGKSCATSQEDFLIYSLNNSLRSLHFDPRD
HSLPFQVISVAGTAIALDYDRRNNRIFFTQKLNSLRGQISYVSLYSGSSS
PTVLLSNIGVTDGIAFDWINRRIYYSDFSNQTINSMAEDGSNRAVIARVS
KPRAIVLDPCRGYMYWTDWGTNAKIERATLGGNFRVPIVNTSLVWPNGLA
LDLETDLLYWADASLQKIERSTLTGTNREVVVSTAFHSFGLTVYGQYIYW
TDLYTRKIYRANKYDGSDLVAMTTRLPTQPSGISTVVKTQRQQCSNPCDQ
FNGGCSHICAPGPNGAECQCPHEGNWYLANDNKYCVVDTGTRCNQLQFTC
LNGHCINQDWKCDNDNDCGDGSDELPTVCAFHTCRSTAFTCGNGRCVPYH
YRCDYYNDCGDNSDEAGC
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8jxe Chain B Residue 4706 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jxe Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		A1331 D1334 V1336 D1338 D1344 E1345
Binding residue
(residue number reindexed from 1)		A23 D26 V28 D30 D36 E37
Annotation score4
External links
PDB RCSB:8jxe, PDBe:8jxe, PDBj:8jxe
PDBsum8jxe
PubMed38771880
UniProtP98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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