Structure of PDB 8egx Chain B Binding Site BS05

Receptor Information

>8egx Chain B (length=425) Species: 9606 (Homo sapiens)

AEPRQVFQVLEEQPPGTLVGTIQTRPGFTYRLSESHALFAINSSTGALYT
TSTIDRESLPSDVINLVVLSSAPTYPTEVRVLVRDLNDNAPVFPDPSIVV
TFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLN
PSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQD
INDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDE
GTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQ
LLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANG
NISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSD
NYGAPPGAAVQARSSVASLVIFVND

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 8egx Chain B Residue 507

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8egx Structure of the planar cell polarity cadherins Fat4 and Dachsous1.
• Resolution: 3.688 Å
• Binding residue (original residue number in PDB): N347 N349 D384 D386 N391 D442
• Binding residue (residue number reindexed from 1): N305 N307 D342 D344 N349 D400
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8egx, PDBe:8egx, PDBj:8egx
• PDBsum: 8egx
• PubMed: 36797229
• UniProt: Q6V0I7|FAT4_HUMAN Protocadherin Fat 4 (Gene Name=FAT4)