Structure of PDB 8d40 Chain B Binding Site BS05

Receptor Information
>8d40 Chain B (length=427) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGRGSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGL
FDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATT
YITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINAN
LRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPG
PLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRD
QGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQ
DGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHI
QAVDADSGENARLHYRLVDTAPDFPFQIHNSSGWITVCAELDREEVEHYS
FGVEAVDHGSPPMSSSTSVSITVLDVN
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8d40 Chain B Residue 507 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8d40 Crystal structure of human CELSR1 EC1-4
Resolution3.554 Å
Binding residue
(original residue number in PDB)		E235 D288 E290 D325
Binding residue
(residue number reindexed from 1)		E233 D286 E288 D323
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8d40, PDBe:8d40, PDBj:8d40
PDBsum8d40
PubMed
UniProtQ9NYQ6|CELR1_HUMAN Cadherin EGF LAG seven-pass G-type receptor 1 (Gene Name=CELSR1)

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