Structure of PDB 7usw Chain B Binding Site BS05

Receptor Information
>7usw Chain B (length=608) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRQALLERIRQKKEVIGKLRCQAWSMTRKRRTLKLAQKYLEQHESKVSRS
HLYMEEMRKRARLMKRSFSNFKTYLIPWESKIKRIESHFGSVVSSYFTFL
RWIVFVNIMITLIALVFVVLPETLADSVANEGRFNRTKTRKQIPANERVH
ADELAVVWHYDGYLRYSPLFYGYYSDDPFLGNKIKYALPLAYFMVTLTIF
AYSFFAILRKMAANARMSKLSGSKAEQYIFNWKLFTGWDYTIGNSETASN
TVMAVVIKLRESIADIKKDAHGKFRLLQFSLRVFANIIICAMLGFSIYCI
IFAVQKSQVQDDGNLFTKNQVPSVVSTITHVFPMIFDLIGKMENYHPRTA
LRAHLGRVLILYTVNYITLIFALFEKMTALRDRVNNDICWETIIGQEIVK
LVTMDLIFTILSILVIDLFRGLWIKYCSSWWCWDIETTFPEYGEFKVAEN
VLHIINNQGMIWLGLFFAPLLPAINNIKLIILMYIRGWAVMTCNVPAREI
FRASRSSNFYLGILLIWLLLCTLPVGFVIASMSPSRSCGPFARYQHFYTV
VTREIEKRVDQTVLSYIRHIASPGVVIPIILFLILIIYFLFSLVRGLREA
NTDLQAQL
Ligand information
Ligand IDZFC
InChIInChI=1S/C11H24O/c1-2-3-4-5-6-7-8-9-10-11-12/h12H,2-11H2,1H3
InChIKeyKJIOQYGWTQBHNH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01OCCCCCCCCCCC
CACTVS 3.370
OpenEye OEToolkits 1.7.6		CCCCCCCCCCCO
FormulaC11 H24 O
Nameundecan-1-ol
ChEMBLCHEMBL444525
DrugBank
ZINCZINC000001596062
PDB chain7usw Chain B Residue 1321 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7usw Structures of the TMC-1 complex illuminate mechanosensory transduction.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		M183 I187 Y276
Binding residue
(residue number reindexed from 1)		M109 I113 Y202
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005272 sodium channel activity
GO:0008381 mechanosensitive monoatomic ion channel activity
Biological Process
GO:0007606 sensory perception of chemical stimulus
GO:0034220 monoatomic ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0050906 detection of stimulus involved in sensory perception
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043025 neuronal cell body
GO:0097730 non-motile cilium

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7usw, PDBe:7usw, PDBj:7usw
PDBsum7usw
PubMed36224384
UniProtD3KZG3|TMC1_CAEEL Transmembrane channel-like protein 1 (Gene Name=tmc-1)

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