Structure of PDB 7thn Chain B Binding Site BS05

Receptor Information
>7thn Chain B (length=478) Species: 104623 (Prodigiosinella confusarubida) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TISTPVIIDSLIRHAQRTPEQTALLCGDQHWNYRQLVTRAHVMASALRQA
GLSGQAILLNLPKSLDAVAAIYATWLSGNHYIPIDYSQPSSRIERIIAAA
APALIIDTAWLATLDSQVYHNPIAAILYTSGSTGTPKGVQISHEMLGFFI
QWAVRDTQLTARDVLSNHASFAFDLSTFDLFASAYVGAATWIIRESEQKD
CAALAQGLQRHAVSVWYSVPSILAMLEKSTLLNPTLGQSLRQVIFAGEPY
PVTALKRLLPCLPQPCRVSNWYGPTETNVCVAYAIDRARLAMLKQVPIGL
PLEGLTAQLEDENGDRHPLTAQLRLSGELLISGPCVTPGYSNVVVPRQAA
LHPHQCHATGDWVEMTPEGLVFRGRIDDMVKINGYRVELGEIESVLHQHP
AIDRAALCVELGDLRQTLIMVISLQTGAVPPGLLELKQFLQQKLPSYMIP
NKLVITESLPVNAKVDRKQLAGVVAVLE
Ligand information
Ligand IDAZI
InChIInChI=1S/N3/c1-3-2/q-1
InChIKeyIVRMZWNICZWHMI-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[N-]=[N+]=[N-]
FormulaN3
NameAZIDE ION
ChEMBLCHEMBL79455
DrugBank
ZINC
PDB chain7thn Chain B Residue 614 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7thn Essential Role of Loop Dynamics in Type II NRPS Biomolecular Recognition.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		R93 Y141 T142
Binding residue
(residue number reindexed from 1)		R92 Y128 T129
Annotation score1
Enzymatic activity
Enzyme Commision number 6.2.1.53: L-proline--[L-prolyl-carrier protein] ligase.
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0031177 phosphopantetheine binding
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0043041 amino acid activation for nonribosomal peptide biosynthetic process
GO:0044550 secondary metabolite biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7thn, PDBe:7thn, PDBj:7thn
PDBsum7thn
PubMed36173802
UniProtQ5W263|PIGI_SERS3 L-proline--[L-prolyl-carrier protein] ligase (Gene Name=pigI)

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