Structure of PDB 7oyx Chain B Binding Site BS05

Receptor Information

>7oyx Chain B (length=347) Species: 83333 (Escherichia coli K-12)

QKTLHIYNWTDYIAPDTVANFEKETGIKVVYDVFDSNEVLEGKLMAGSTG
FDLVVPSASYLERQLTAGVFQPLDKSKLPEWKNLDPELLKLVAKHDPDNK
FAMPYMWATTGIGYNVDKVKAVLGENAPVDSWDLILKPENLEKLKSCGVS
FLDDPEEVFATVLNYLGKDPNSTKADDYTGPATDLLLKLRPNIRYFHSSQ
YINDLANGDICVAIGWAGDVWQASNRAKEAKNGVNVSFSIPKEGAMAWFD
VFAMPADAKNKDEAYQFLNYLLRPDVVAHISDHVFYANANKAATPLVSAE
VRENPGIYPPADVRAKLFTQKVQDPKIDRVRTRAWTKVKSGKLEHHH

Ligand information

• Ligand ID: 3IE
• InChI: InChI=1S/C4H11NO/c1-4(5)3-6-2/h4H,3,5H2,1-2H3/t4-/m0/s1
• InChIKey: NXMXETCTWNXSFG-BYPYZUCNSA-N
• SMILES:
  CACTVS 3.385: COC[C@H](C)N
  OpenEye OEToolkits 2.0.7: CC(COC)N
  CACTVS 3.385: COC[CH](C)N
  OpenEye OEToolkits 2.0.7: C[C@@H](COC)N
• Formula: C4 H11 N O
• Name: (2~{S})-1-methoxypropan-2-amine
• ZINC: ZINC000002572631
• PDB chain: 7oyx Chain B Residue 405

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7oyx Fine-tuning spermidine binding modes in the putrescine binding protein PotF.
• Resolution: 1.37 Å
• Binding residue (original residue number in PDB): W135 R342
• Binding residue (residue number reindexed from 1): W107 R314
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0019808 polyamine binding
• GO:0019810 putrescine binding

Biological Process

• GO:0015846 polyamine transport
• GO:0015847 putrescine transport

Cellular Component

• GO:0016020 membrane
• GO:0030288 outer membrane-bounded periplasmic space
• GO:0042597 periplasmic space
• GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

External links

• PDB: RCSB:7oyx, PDBe:7oyx, PDBj:7oyx
• PDBsum: 7oyx
• PubMed: 34801550
• UniProt: P31133|POTF_ECOLI Putrescine-binding periplasmic protein PotF (Gene Name=potF)