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Receptor Information

>7lft Chain B (length=450) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDY
VSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIP
TDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVM
YIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYW
STLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNA
ARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLK
YLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDY
ICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGS
KAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMK

Ligand ID

CPL

InChI

InChI=1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1

InChIKey

JLPULHDHAOZNQI-ZTIMHPMXSA-N

SMILES

Software	SMILES
ACDLabs 10.04	O=C(OCC(OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COP([O-])(=O)OCC[N+](C)(C)C)CCCCCCCCCCCCCCC
OpenEye OEToolkits 1.5.0	CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCC=CCCCCC
CACTVS 3.341	CCCCCCCCCCCCCCCC(=O)OC[CH](CO[P]([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCC=CCCCCC
CACTVS 3.341	CCCCCCCCCCCCCCCC(=O)OC[C@H](CO[P]([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C/C=C\CCCCC
OpenEye OEToolkits 1.5.0	CCCCCCCCCCCCCCCC(=O)OC[C@H](CO[P@@](=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC

Formula

C42 H80 N O8 P

Name

1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE;
PALMITOYL-LINOLEOYL PHOSPHATIDYLCHOLINE

PDB chain

7lft Chain B Residue 706 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7lft Structural mechanisms of gating and selectivity of human rod CNGA1 channel.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	R371 D372 S373 V376 L383
Binding residue (residue number reindexed from 1)	R216 D217 S218 V221 L228
Annotation score	1

Enzyme Commision number

	Molecular Function
GO:0005216	monoatomic ion channel activity
GO:0005221	intracellularly cyclic nucleotide-activated monoatomic cation channel activity

	Biological Process
GO:0006811	monoatomic ion transport
GO:0055085	transmembrane transport

	Cellular Component
GO:0016020	membrane

PDB	RCSB:7lft, PDBe:7lft, PDBj:7lft
PDBsum	7lft
PubMed	33651975
UniProt	P29973\|CNGA1_HUMAN Cyclic nucleotide-gated channel alpha-1 (Gene Name=CNGA1)

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Structure of PDB 7lft Chain B Binding Site BS05