Structure of PDB 7eun Chain B Binding Site BS05
Receptor Information
>7eun Chain B (length=274) Species:
1914
(Streptomyces lavendulae) [
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MIDLIVSQGRVADRAAWMIEGAARTARALEERYGLKGHYVGEPAPHADDD
WSVALPQARETLVAVREAATESIKGDNLTVLVNNTCSVSLATLPVVAREH
PDAVVLYIDGHGDFNTPETTDTGYLGGMVLSGACGLWDSGHGAGLRPEQA
VLVGSRDIDEGERELIRKAGVRVIPPGEATAQAVLDAVKDAPVWIHIDWD
VLEPGSIPADYTVPDGMLPAQIRAVFEAIPAERLIGVELAELNAPADSER
AEQAVAVILDMVAPAFDAAAARPL
Ligand information
Ligand ID
ABH
InChI
InChI=1S/C6H15BNO5/c8-5(6(9)10)3-1-2-4-7(11,12)13/h5,11-13H,1-4,8H2,(H,9,10)/q-1/t5-/m0/s1
InChIKey
BLVGFZFOWWBCCZ-YFKPBYRVSA-N
SMILES
Software
SMILES
CACTVS 3.341
N[C@@H](CCCC[B-](O)(O)O)C(O)=O
ACDLabs 10.04
O=C(O)C(N)CCCC[B-](O)(O)O
OpenEye OEToolkits 1.5.0
[B-](CCCCC(C(=O)O)N)(O)(O)O
OpenEye OEToolkits 1.5.0
[B-](CCCC[C@@H](C(=O)O)N)(O)(O)O
CACTVS 3.341
N[CH](CCCC[B-](O)(O)O)C(O)=O
Formula
C6 H15 B N O5
Name
2(S)-AMINO-6-BORONOHEXANOIC ACID
ChEMBL
DrugBank
DB01983
ZINC
ZINC000169748469
PDB chain
7eun Chain B Residue 405 [
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Receptor-Ligand Complex Structure
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PDB
7eun
Catalytic mechanism of DcsB: Arginase framework used for hydrolyzing its inhibitor.
Resolution
1.28 Å
Binding residue
(original residue number in PDB)
C86 D109 H111 D113 T122 G126 D159 D198 D210 Y211 E241
Binding residue
(residue number reindexed from 1)
C86 D109 H111 D113 T122 G126 D159 D198 D210 Y211 E241
Annotation score
2
Enzymatic activity
Enzyme Commision number
3.5.3.25
: N(omega)-hydroxy-L-arginine amidinohydrolase.
Gene Ontology
Molecular Function
GO:0004053
arginase activity
GO:0016787
hydrolase activity
GO:0016813
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
GO:0030145
manganese ion binding
GO:0046872
metal ion binding
Biological Process
GO:0017000
antibiotic biosynthetic process
GO:0019547
arginine catabolic process to ornithine
Cellular Component
GO:0005737
cytoplasm
GO:0005829
cytosol
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:7eun
,
PDBe:7eun
,
PDBj:7eun
PDBsum
7eun
PubMed
35634777
UniProt
D2Z025
|DCSB_STRLA N(omega)-hydroxy-L-arginine amidinohydrolase (Gene Name=dcsB)
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