Structure of PDB 7eun Chain B Binding Site BS05

Receptor Information
>7eun Chain B (length=274) Species: 1914 (Streptomyces lavendulae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIDLIVSQGRVADRAAWMIEGAARTARALEERYGLKGHYVGEPAPHADDD
WSVALPQARETLVAVREAATESIKGDNLTVLVNNTCSVSLATLPVVAREH
PDAVVLYIDGHGDFNTPETTDTGYLGGMVLSGACGLWDSGHGAGLRPEQA
VLVGSRDIDEGERELIRKAGVRVIPPGEATAQAVLDAVKDAPVWIHIDWD
VLEPGSIPADYTVPDGMLPAQIRAVFEAIPAERLIGVELAELNAPADSER
AEQAVAVILDMVAPAFDAAAARPL
Ligand information
Ligand IDABH
InChIInChI=1S/C6H15BNO5/c8-5(6(9)10)3-1-2-4-7(11,12)13/h5,11-13H,1-4,8H2,(H,9,10)/q-1/t5-/m0/s1
InChIKeyBLVGFZFOWWBCCZ-YFKPBYRVSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[C@@H](CCCC[B-](O)(O)O)C(O)=O
ACDLabs 10.04O=C(O)C(N)CCCC[B-](O)(O)O
OpenEye OEToolkits 1.5.0[B-](CCCCC(C(=O)O)N)(O)(O)O
OpenEye OEToolkits 1.5.0[B-](CCCC[C@@H](C(=O)O)N)(O)(O)O
CACTVS 3.341N[CH](CCCC[B-](O)(O)O)C(O)=O
FormulaC6 H15 B N O5
Name2(S)-AMINO-6-BORONOHEXANOIC ACID
ChEMBL
DrugBankDB01983
ZINCZINC000169748469
PDB chain7eun Chain B Residue 405 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7eun Catalytic mechanism of DcsB: Arginase framework used for hydrolyzing its inhibitor.
Resolution1.28 Å
Binding residue
(original residue number in PDB)
C86 D109 H111 D113 T122 G126 D159 D198 D210 Y211 E241
Binding residue
(residue number reindexed from 1)
C86 D109 H111 D113 T122 G126 D159 D198 D210 Y211 E241
Annotation score2
Enzymatic activity
Enzyme Commision number 3.5.3.25: N(omega)-hydroxy-L-arginine amidinohydrolase.
Gene Ontology
Molecular Function
GO:0004053 arginase activity
GO:0016787 hydrolase activity
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0019547 arginine catabolic process to ornithine
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7eun, PDBe:7eun, PDBj:7eun
PDBsum7eun
PubMed35634777
UniProtD2Z025|DCSB_STRLA N(omega)-hydroxy-L-arginine amidinohydrolase (Gene Name=dcsB)

[Back to BioLiP]