Structure of PDB 6qcx Chain B Binding Site BS05

Receptor Information
>6qcx Chain B (length=747) Species: 1601067 (Influenza B virus (B/Memphis/13/2003)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMNINPYFLFIDVPIQAAISTTFPYTGVPPYSHGTGTGYTIDTVIRTHEY
SNKGKQYISDVTGCTMVDPTNGPLPEDNEPSAYAQLDCVLEALDRMDEEH
PGLFQAASQNAMETLMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITS
FRLNDLNGADKGGLIPFCQDIIDSLDRPEMTFFSVKNIKKKLPAKNRKGF
LIKRIPMKVKDKITKVEYIKRALSLNTMTKDAERGKLKRRAIATAGIQIR
GFVLVVENLAKNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPGGIS
MTVTGDNTKWNECLNPRIFLAMTERITRDSPIWFRDFCSIAPVLFSNKIA
RLGKGFMITSKTKRLKAQIPCPDLFSIPLERYNEETRAKLKKLKPFFNEE
GTASLSPGMMMGMFNMLSTVLGVAALGIKNIGNKEYLWDGLQSSDDFALF
VNAKDEETCMEGINDFYRTCKLLGINMSKKKSYCNETGMFEFTSMFYRDG
FVSNFAMELPSFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQTAIQL
FIADYRYTYKCHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNIYN
LRNLHIPEIVLKYNLMDPEYKGRLLHPQNPFVGHLSIKEADITPAHGPVK
KMDYDAVSGTHSWRTKRNRSILNTDQRNMILEEQCYAKCCNLFEACFNSA
SYRKPVGQHSMLEAMAHRLRMDARLDYESGRMSKDDFEKAMAHLGEI
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6qcx Chain B Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6qcx Structural snapshots of actively transcribing influenza polymerase.
Resolution3.08 Å
Binding residue
(original residue number in PDB)		D305 N306 D444
Binding residue
(residue number reindexed from 1)		D306 N307 D445
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qcx, PDBe:6qcx, PDBj:6qcx
PDBsum6qcx
PubMed31160782
UniProtQ5V8Y6

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