Structure of PDB 6gyp Chain B Binding Site BS05

Receptor Information
>6gyp Chain B (length=527) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSKEYLPDLLLFWQNYEYWITNIGLYKTKQRDLTRTPANLDTDTEECMFW
MNYLQKDQSFQLMNFAMENLGALYFGSIGDISELYLRVEQYWDRRADKNH
SVDGKYWDALIWSVFTMCIYYMPVEKLAEIFSVYPLHEYLGSNKRLNWED
GMQLVMCQNFARCSLFQLKQCDFMAHPDIRLVQAYLILATTTFPYDEPLL
ANSLLTQCIHTFKNFHVDDFRPLLNDDPVESIAKVTLGRIFYRLCGCDYL
QSGPRKPIALHTEVSSLNVDVYREENSTEVLYWKIISLDRDLDQYLNKSS
KPPLKTLDAIRRELDIFQYKVDSLEEDFRSNNSRFQKFIALFQISTVSWK
LFKMYLIYYDTADSLLKVIHYSKVIISLIVNNFHAKSEFFNRHPMVMQTI
TRVVSFISFYQIFVESAAVKQLLVDLTELTANLPTIFGSKLDKLVYLTER
LSKLKLLWDKVQLLDSGDSFYHPVFKILQNDIKIIELKNDEMFSLIKGLG
SLVPLNSDFRTIVEEFQSEYNISDILS
Ligand information
Ligand IDTHR
InChIInChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1
InChIKeyAYFVYJQAPQTCCC-GBXIJSLDSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(N)C(O)C
OpenEye OEToolkits 1.5.0CC(C(C(=O)O)N)O
CACTVS 3.341C[CH](O)[CH](N)C(O)=O
CACTVS 3.341C[C@@H](O)[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0C[C@H]([C@@H](C(=O)O)N)O
FormulaC4 H9 N O3
NameTHREONINE
ChEMBLCHEMBL291747
DrugBankDB00156
ZINCZINC000000895103
PDB chain6gyp Chain B Residue 705 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6gyp Architecture of the CBF3-centromere complex of the budding yeast kinetochore.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		E56 D60
Binding residue
(residue number reindexed from 1)		E4 D8
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008301 DNA binding, bending
GO:0019237 centromeric DNA binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000921 septin ring assembly
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007094 mitotic spindle assembly checkpoint signaling
GO:0051382 kinetochore assembly
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005694 chromosome
GO:0031518 CBF3 complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6gyp, PDBe:6gyp, PDBj:6gyp
PDBsum6gyp
PubMed30478265
UniProtP40969|CBF3B_YEAST Centromere DNA-binding protein complex CBF3 subunit B (Gene Name=CEP3)

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