Structure of PDB 6cq8 Chain B Binding Site BS05

Receptor Information
>6cq8 Chain B (length=282) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDSAINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPQEISQRTTIVIQR
EKFLRAHPCVSDQELDELIQQIVAAINAGIIPLGASSNQVSHWDLGSSFF
FAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTI
FGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAVIFKHIE
GWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAY
FAAVLSMIGDWLRVIAKKTKEAVGEFRAHAAE
Ligand information
Ligand IDQ6F
InChIInChI=1S/C15H14Cl2N2O3S/c1-23(21,22)19-13-6-3-10(4-7-13)15(20)18-9-11-2-5-12(16)8-14(11)17/h2-8,19H,9H2,1H3,(H,18,20)
InChIKeyRDFIQTZRJRVFHK-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385C[S](=O)(=O)Nc1ccc(cc1)C(=O)NCc2ccc(Cl)cc2Cl
ACDLabs 12.01c1(ccc(cc1)NS(C)(=O)=O)C(NCc2c(cc(cc2)Cl)Cl)=O
OpenEye OEToolkits 2.0.6CS(=O)(=O)Nc1ccc(cc1)C(=O)NCc2ccc(cc2Cl)Cl
FormulaC15 H14 Cl2 N2 O3 S
NameN-[(2,4-dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]benzamide
ChEMBL
DrugBank
ZINCZINC000001050726
PDB chain6cq8 Chain B Residue 410 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6cq8 K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		S131 F134 G137 A259 G260 G261 K271 V274 W275 I278
Binding residue
(residue number reindexed from 1)		S97 F100 G103 A225 G226 G227 K237 V240 W241 I244
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
Biological Process
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6cq8, PDBe:6cq8, PDBj:6cq8
PDBsum6cq8
PubMed28693035
UniProtP97438|KCNK2_MOUSE Potassium channel subfamily K member 2 (Gene Name=Kcnk2)

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