Structure of PDB 5wri Chain B Binding Site BS05

Receptor Information
>5wri Chain B (length=273) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AYHKDMPLIFIGGVPRSGTTLMRAMLDAHPDIRCGEETRVIPRILALKQM
WSRSSKEKIRLDEAGVTDEVLDSAMQAFLLEIIVKHGEPAPYLCNKDPFA
LKSLTYLSRLFPNAKFLLMVRDGRASVHSMISRKVTIAGFDLNSYRDCLT
KWNRAIETMYNQCMEVGYKKCMLVHYEQLVLHPERWMRTLLKFLQIPWNH
SVLHHEEMIGKAGGVSLSKVERSTDQVIKPVNVGALSKWVGKIPPDVLQD
MAVIAPMLAKLGYDPYANPPNYG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5wri Chain B Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5wri Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		H267 E269
Binding residue
(residue number reindexed from 1)		H204 E206
Annotation score1
Enzymatic activity
Enzyme Commision number 2.8.2.20: protein-tyrosine sulfotransferase.
Gene Ontology
Molecular Function
GO:0008476 protein-tyrosine sulfotransferase activity
Biological Process
GO:0006478 peptidyl-tyrosine sulfation

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Molecular Function
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Biological Process
External links
PDB RCSB:5wri, PDBe:5wri, PDBj:5wri
PDBsum5wri
PubMed28821720
UniProtO60507|TPST1_HUMAN Protein-tyrosine sulfotransferase 1 (Gene Name=TPST1)

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