Structure of PDB 5v2k Chain B Binding Site BS05

Receptor Information
>5v2k Chain B (length=444) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KRGHVLAVPYPAQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLS
GPISIATISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDN
PITCIVYDAFLPWALDVAREFGLVATPFFTQPCAVNYVYYLSYINNGSLQ
LPIEELPFLELQDLPSFFSVSGSYPAYFEMVLQQFINFEKADFVLVNSFQ
ELELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKDDSF
CINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRSSEE
EKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALT
FGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIK
EVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRVQ
Ligand information
Ligand ID7WV
InChIInChI=1S/C7H5BrO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,(H,9,10)
InChIKeyXRXMNWGCKISMOH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385OC(=O)c1ccccc1Br
OpenEye OEToolkits 2.0.6c1ccc(c(c1)C(=O)O)Br
ACDLabs 12.01c1ccc(c(c1)C(O)=O)Br
FormulaC7 H5 Br O2
Name2-bromobenzoic acid
ChEMBLCHEMBL115950
DrugBank
ZINCZINC000000164706
PDB chain5v2k Chain B Residue 504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5v2k Differences in salicylic acid glucose conjugations by UGT74F1 and UGT74F2 from Arabidopsis thaliana.
Resolution2.002 Å
Binding residue
(original residue number in PDB)		Y13 H18 F113 Q134 Y180 M183 M274 T365
Binding residue
(residue number reindexed from 1)		Y10 H15 F110 Q131 Y177 M180 M271 T362
Annotation score2
Enzymatic activity
Enzyme Commision number 2.4.1.-
Gene Ontology
Molecular Function
GO:0008194 UDP-glycosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0035251 UDP-glucosyltransferase activity
GO:0052639 salicylic acid glucosyltransferase (ester-forming) activity
GO:0052640 salicylic acid glucosyltransferase (glucoside-forming) activity
GO:0052641 benzoic acid glucosyltransferase activity
GO:0080002 UDP-glucose:4-aminobenzoate acylglucosyltransferase activity
GO:0090704 nicotinate-O-glucosyltransferase activity
Biological Process
GO:0009696 salicylic acid metabolic process
GO:0010030 positive regulation of seed germination
GO:0018874 benzoate metabolic process
GO:0046482 para-aminobenzoic acid metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5v2k, PDBe:5v2k, PDBj:5v2k
PDBsum5v2k
PubMed28425481
UniProtO22822|U74F2_ARATH UDP-glycosyltransferase 74F2 (Gene Name=UGT74F2)

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