Structure of PDB 5u6n Chain B Binding Site BS05

Receptor Information
>5u6n Chain B (length=448) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEHKRGHVLAVPYPSQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINP
DLSGPISIATISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQT
SDNPITCIVYDAFLPWALDVAREFGLVATPFFTQPCAVNYVYYLSYINNG
SLQLPIEELPFLELQDLPSFFSVSGSYPAYFEMVLQQFINFEKADFVLVN
SFQELELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKD
DSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRS
SEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTME
ALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEF
SIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRVQS
Ligand information
Ligand IDSAL
InChIInChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)
InChIKeyYGSDEFSMJLZEOE-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)c1ccccc1O
OpenEye OEToolkits 1.5.0c1ccc(c(c1)C(=O)O)O
CACTVS 3.341OC(=O)c1ccccc1O
FormulaC7 H6 O3
Name2-HYDROXYBENZOIC ACID;
SALICYLIC ACID
ChEMBLCHEMBL424
DrugBankDB00936
ZINCZINC000000001554
PDB chain5u6n Chain B Residue 504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5u6n Differences in salicylic acid glucose conjugations by UGT74F1 and UGT74F2 from Arabidopsis thaliana.
Resolution2.001 Å
Binding residue
(original residue number in PDB)		S15 H18 F113 Q134 M274 T365
Binding residue
(residue number reindexed from 1)		S15 H18 F113 Q134 M274 T365
Annotation score2
Enzymatic activity
Enzyme Commision number 2.4.1.-
Gene Ontology
Molecular Function
GO:0008194 UDP-glycosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0035251 UDP-glucosyltransferase activity
GO:0052639 salicylic acid glucosyltransferase (ester-forming) activity
GO:0052640 salicylic acid glucosyltransferase (glucoside-forming) activity
GO:0052641 benzoic acid glucosyltransferase activity
GO:0080002 UDP-glucose:4-aminobenzoate acylglucosyltransferase activity
GO:0090704 nicotinate-O-glucosyltransferase activity
Biological Process
GO:0009696 salicylic acid metabolic process
GO:0010030 positive regulation of seed germination
GO:0018874 benzoate metabolic process
GO:0046482 para-aminobenzoic acid metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5u6n, PDBe:5u6n, PDBj:5u6n
PDBsum5u6n
PubMed28425481
UniProtO22822|U74F2_ARATH UDP-glycosyltransferase 74F2 (Gene Name=UGT74F2)

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