Structure of PDB 4oav Chain B Binding Site BS05

Receptor Information
>4oav Chain B (length=673) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSRED
IVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDF
YGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALM
DAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITH
LLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDG
KTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSH
GAKEWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYL
GFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLF
VCVTLCEQTLEACLDVEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQ
NILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISF
EDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTW
ESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINEC
VMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGENIDKMKLKIGDPSLYFQK
TFPDLVIYVYTKLQNTEYRKHFP
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4oav Chain B Residue 803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4oav Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		D503 D505
Binding residue
(residue number reindexed from 1)		D464 D466
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0004540 RNA nuclease activity
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019843 rRNA binding
GO:0043021 ribonucleoprotein complex binding
GO:0046872 metal ion binding
Biological Process
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0043488 regulation of mRNA stability
GO:0045071 negative regulation of viral genome replication
GO:0045444 fat cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046326 positive regulation of D-glucose import
GO:0051607 defense response to virus
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0016363 nuclear matrix

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4oav, PDBe:4oav, PDBj:4oav
PDBsum4oav
PubMed24578532
UniProtQ05823|RN5A_HUMAN 2-5A-dependent ribonuclease (Gene Name=RNASEL)

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