Structure of PDB 3q23 Chain B Binding Site BS05

Receptor Information
>3q23 Chain B (length=1094) Species: 10752 (Enquatrovirus N4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TEELKEGIDAVYPSLVGTADSKAEGIKNYFKLSFTLPEEQKSRTVGSEAP
LKDVAQALSSRARYELFTEKETANPAFNGEVIKRYKELMEHGEGIADILR
SRLAKFLNTKDVGKRFAQGTEANRWVGGKLLNIVEQDGDTFKYNEQLLQT
AVLAGLQWRLTATSNTAIKDAKDVAAITGIDQALLPEGLVEQFDTGMTLT
EAVSSLAQKIESYWGLSRNPNAPLGYTKGIPTAMAAEILAAFVESTDVVE
NIVDMSEIDPDNKKTIGLYTITELDSFDPINSFPTAIEEAVLVNPTEKMF
FGDDIPPVANTQLRNPAVRNTPEQKAALKAEQATEFYVHTPMVQFYETLG
KDRILELMGAGTLNKELLNDNHAKSLEGKNRSVEDSYNQLFSVIEQVRAQ
SEDISTVPIHYAYNMTRVGRMQMLGKYNPQSAKLVREAILPTKATLDLSN
QNNEDFSAFQLGLAQALDIKVHTMTREVMSDELTKLLEGNLKPAIDMMVE
FNTTGSLPENAVDVLNTALGDRKSFVALMALMEYSRYLVAEDKSAFVTPL
YVEADGVTNGPINAMMLMTGGLFTPDWIRNIAKGGLFIGSPNKTMNEHRS
TADNNDLYQASTNALMESLGKLRSNYASNMPIQSQIDSLLSLMDLFLPDI
NLGENGALELKRGIAKNPLTITIYGSGARGIAGKLVSSVTDAIYERMSDV
LKARAKDPNISAAMAMFGKQAASEAHAEELLARFLKDMETLTSTVPVKRK
GVLELQSTGTGAKGKINPKTYTIKGEQLKALQENMLHFFVEPLRNGITQT
VGESLVYSTEQLQKATQIQSVVLEDMFKQRVQEKLAEKAKDPTWKKGDFL
TQKELNDIQASLNNLAPMIETGSQTFYIAGSENAEVANQVLATNLDDRMR
VPMSIYAPAQAGVAGIPFMTIGTGDGMMMQTLSTMKGAPKNTLKIFDGMN
IGLNDITDASRKANEAVYTSWQGNPIKNVYESYAKFMKNVDFSKLSPEAL
EAIGKSALEYDQRENATVDDIANAASLIERNLRNIALGVDIRHKVLDKVN
LSIDQMAAVGAPYQNNGKIDLSNMTPEQQADELNKLFREELEAR
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain3q23 Chain B Residue 1110 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3q23 X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		D559 G560 D951
Binding residue
(residue number reindexed from 1)		D555 G556 D947
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
External links
PDB RCSB:3q23, PDBe:3q23, PDBj:3q23
PDBsum3q23
PubMed21321236
UniProtQ859P9|RPOLV_BPN4 Virion DNA-directed RNA polymerase (Gene Name=50)

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