Structure of PDB 2gsm Chain B Binding Site BS05

Receptor Information

>2gsm Chain B (length=256) Species: 1063 (Cereibacter sphaeroides)

LEIIGRPQPGGTGFQPSASPVATQIHWLDGFILVIIAAITIFVTLLILYA
VWRFHEKRNKVPARFTHNSPLEIAWTIVPIVILVAIGAFSLPVLFNQQEI
PEADVTVKVTGYQWYWGYEYPDEEISFESYMIGSPATGGDNRMSPEVEQQ
LIEAGYSRDEFLLATDTAMVVPVNKTVVVQVTGADVIHSWTVPAFGVKQD
AVPGRLAQLWFRAEREGIFFGQCSELCGISHAYMPITVKVVSEEAYAAWL
EQHHHH

Ligand information

• Ligand ID: CD
• InChI: InChI=1S/Cd/q+2
• InChIKey: WLZRMCYVCSSEQC-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Cd++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cd+2]
• Formula: Cd
• Name: CADMIUM ION
• PDB chain: 2gsm Chain B Residue 3008

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2gsm Identification of conserved lipid/detergent-binding sites in a high-resolution structure of the membrane protein cytochrome c oxidase.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): E280 H283 H285
• Binding residue (residue number reindexed from 1): E251 H254 H256
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 7.1.1.9: cytochrome-c oxidase.

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0005507 copper ion binding
• GO:0005515 protein binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0022900 electron transport chain
• GO:0042773 ATP synthesis coupled electron transport
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:2gsm, PDBe:2gsm, PDBj:2gsm
• PDBsum: 2gsm
• PubMed: 17050688
• UniProt: Q03736|COX2_CERSP Cytochrome c oxidase subunit 2 (Gene Name=ctaC)