Structure of PDB 8w8e Chain A Binding Site BS05

Receptor Information
>8w8e Chain A (length=1426) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCV
CFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNGGCGRYQP
RIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGME
PRYARPEWMIVTVLPVPPLSVRPAVRNQDDLTHKLADIVKINNQLRRNEQ
NGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKG
KEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVT
PFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYK
VERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNAD
FDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAV
RKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLI
IPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSL
GTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIAD
SKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRIL
NDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEG
KRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGRE
GLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDG
LAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSN
AHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFH
INPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHL
RSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSL
GEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLTVFLLG
QSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNV
YYEMPDFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNC
IFNDDNAEKLVLRIRIMNDDDVFLRCIESNMLTDMTLQGIEQISKVYMHL
PQTDNKKKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSND
IVEIFTVLGIEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGHL
MAITRHGVNRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLG
QLAPAGTGCFDLLLDAEKCKYGMEIP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8w8e Chain A Residue 2002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8w8e Strcutures of co-transcriptional RNA capping enzymes on paused transcription complex
Resolution3.9 Å
Binding residue
(original residue number in PDB)		C111 C114
Binding residue
(residue number reindexed from 1)		C101 C104
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8w8e, PDBe:8w8e, PDBj:8w8e
PDBsum8w8e
PubMed38816438
UniProtA0A8D1DPV6

[Back to BioLiP]