Structure of PDB 8vby Chain A Binding Site BS05

Receptor Information
>8vby Chain A (length=553) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMV
IAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYN
VIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPNDTFGTTPAAEYF
ERGVLHLHQSHGIDDLGPPRWQLTACLVLVYVLLYFSLWKGVKTSGKVVW
ITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQ
VCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSF
LGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLT
LGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNG
GIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPS
LYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATS
SMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHW
LKV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8vby Chain A Residue 713 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8vby Structure of the human dopamine transporter and mechanisms of inhibition
Resolution3.19 Å
Binding residue
(original residue number in PDB)		D191 H193 H375 E396
Binding residue
(residue number reindexed from 1)		D134 H136 H308 E329
Annotation score1
External links
PDB RCSB:8vby, PDBe:8vby, PDBj:8vby
PDBsum8vby
PubMed39112705
UniProtQ01959|SC6A3_HUMAN Sodium-dependent dopamine transporter (Gene Name=SLC6A3)

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