Structure of PDB 8uhg Chain A Binding Site BS05

Receptor Information
>8uhg Chain A (length=1399) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDPR
QGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVC
FFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGCGRY
QPRIRRSGLELYAEWKILLSPERVHEIFKRISDEECFVLGMEPRYARPEW
MIVTVSARNQDDLTHKLADIVKINNQLRRNEQNGAAAHVIAEDVKLLQFH
VATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVDFSA
RTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQY
PGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPT
LHKMSMMGHRVRILPWSTFRLNLSVTTPYNADFDGDEMNLHLPQSLETRA
EIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKRDVFLERGEVMNL
LMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHINCIRTHSTHPDDE
DSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEMGHD
ITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDV
IEVIEKAHNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEY
NNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKD
DYGPESRGFVENSYLAGLTPTEFFFHAMGGREGLIDTAVKTAETGYIQRR
LIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGESVEFQNLATLKPSN
KAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMREDR
EVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGV
KELSKKLVIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGE
AFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPATQMTLNKNVTLGVP
RLKELINISKKPKTPSLTVFLLGQSARDAERAKDILCRLEHTTLRKVTAN
TAIYYDPNPQSTVVAEDQEWVNVYYEMPDFDVARISPWLLRVELDRKHMT
DRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRIMNSDDDDVFLR
CIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKALQEWIL
ETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALERELYHVI
SFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETV
DVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGME
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8uhg Chain A Residue 2002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8uhg Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		C111 C114 C154
Binding residue
(residue number reindexed from 1)		C100 C103 C143
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8uhg, PDBe:8uhg, PDBj:8uhg
PDBsum8uhg
PubMed38401543
UniProtA0A8D1DPV6

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