Structure of PDB 8u85 Chain A Binding Site BS05

Receptor Information
>8u85 Chain A (length=619) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEDARWLRWVTQQFKTIISLQEFKAALHVESFFAERFFALFDTLQELQEA
LTLLIHSPMDKLKFLFQVYDIDPDELRTVLQSCLRESAISLPDEKLDQLT
LALFESADNGAITFEELRDELQRFPGVMENLTISAAQLTRAYWHNHRSQL
FCLATYAGLHVLLFGLAASAHRDLGASVMVAKGCGQCLNFDCSFIAVLML
RRCLTWLRATWLAQVLPLDQNIQFHQLMGYVVVGLSLVHTVAHTVNFVLQ
AQHGSASPTGVALLLLLLLMFICSSSCIRRSGHFEVFYWTHLSYLLVWLL
LIFHGPNFWKWLLVPGILFFLEKAIGLAVSRMAAVCIMEVNLLPSKVTHL
LIKRPPFFHYRPGDYLYLNIPTIARYEWHPFTISSAPEQKDTIWLHIRSQ
GQWTNRLYESFKASCNIKCYIDGPYGTPTRRIFASEHAVLIGAGIGITPF
ASILQSIMYRHQKRKHTCPSCQHSWIEGVQDNMKLHKVDFIWINRDQRSF
EWFVSLLTKLEMDQAEEAQYGRFLELHMYMTSALGKNDMKAIGLQMALDL
LANKEKKDSITGLQTRTQPGRPDWSKVFQKVAAEKKGKVQVFFCGSPALA
KVLKGHCEKFGFRFFQENF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8u85 Chain A Residue 806 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8u85 Structural Basis of Human NOX5 Activation
Resolution3.2 Å
Binding residue
(original residue number in PDB)		C568 C571
Binding residue
(residue number reindexed from 1)		C468 C471
Annotation score1
Enzymatic activity
Enzyme Commision number 1.6.3.-
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0015252 proton channel activity
GO:0016175 superoxide-generating NAD(P)H oxidase activity
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
GO:0106292 superoxide-generating NADPH oxidase activity
Biological Process
GO:0001525 angiogenesis
GO:0001819 positive regulation of cytokine production
GO:0001935 endothelial cell proliferation
GO:0006915 apoptotic process
GO:0006952 defense response
GO:0034220 monoatomic ion transmembrane transport
GO:0042554 superoxide anion generation
GO:0043012 regulation of fusion of sperm to egg plasma membrane
GO:0061640 cytoskeleton-dependent cytokinesis
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0043020 NADPH oxidase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8u85, PDBe:8u85, PDBj:8u85
PDBsum8u85
PubMed
UniProtQ96PH1|NOX5_HUMAN NADPH oxidase 5 (Gene Name=NOX5)

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