Structure of PDB 8u0p Chain A Binding Site BS05

Receptor Information
>8u0p Chain A (length=322) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKWVCAQPSSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINAL
KSFHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLE
LFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLER
MPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPD
GRSHRGIFSRLLDSLRQEGFLTDDLVSQGKYLGVCRLPGPGRRHRRLDII
VVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVGRVLPT
PTEKDVFRLLGLPYREPAERDW
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8u0p Chain A Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8u0p DNA polymerase lambda Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		D427 D429 D490
Binding residue
(residue number reindexed from 1)		D191 D193 D248
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:8u0p, PDBe:8u0p, PDBj:8u0p
PDBsum8u0p
PubMed38428373
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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