Structure of PDB 8tlq Chain A Binding Site BS05

Receptor Information
>8tlq Chain A (length=1283) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDYFRIQLNNQDYYMSKPTFLDPSHGESLPLNQFSQVPNIRVFGALPTGH
QVLCHVHGILPYMFIKYDGQITDTSTLRHQRCAQVHKTLEVKIRASFKKL
GNLNFVADVSVVKGIPFYGYHVGWNLFYKISLLNPSCLSRISELIRDGKI
FGKKFEIYESHIPYLLQWTADFNLFGCSWINVDRCYFRSPVLNSILDIDK
LTINDDLQLLLDRFCDFKCNVLSRRDFPRVGNGLIEIDILPQFIKNREKL
QHRDIHHDFLEKLGDIKPYVSSARDMINELTMQREELSLKEYKEPPETKR
HVHQWQSSGEFEAFYKKAQHKTSTFDGQIPNFENFIDKNQKFSAINTPYE
ALPQLWPRLPGLRYGKRAFVYGEPPFGYQDILNKLEDEGFPKIDYKDPFF
SNPVDLENKPYAYAGKRFEISSTHVSTRIPVQFGGETVSVYNKPTFDMFS
SWKYALKPPTYDAVQKWYNKVSSVHDSLTHLTLEIHANTRSDKIPDPAID
EVSMIIWCLEEETFPLDLDIAYEGIMIVHKASEDSTFPTKIQHCINEIPV
MFYESEFEMFEALTDLVLLLDPDILSGFEIHNFSWGYIIERCQKIHQFDI
VRELARVKCQIKLSDTWGYAHSSGIMITGRHMINIWRALRSDVNLTQYTI
ESAAFNILHKRLPHFSFESLTNMWNAKKSTTELKTVLNYWLSRAQINIQL
LRKQDYIARNIEQARLIGIDFHSVYYRGSQFKVESFLIRICKSESFILLS
PGKKDVRKQKALECVPLVMEPESAFYKSPLIVLDFQSLYPSIMIGYNYCY
STMIGRVREINLTENNLGVSKFSLPRNILALLKNDVTIAPNGVVYAKTSV
RKSTLSKMLTDILDVRVMIKKTMNEIGDDNTTLKRLLNNKQLALKLLANV
TYGYTSASFSGRMPCSDLADSIVQTGRETLEKAIDIIEKDETWNAKVVYG
DTDSLFVYLPGKTAIEAFSIGHAMAERVTQNNPKPIFLKFEKVYHPSILI
SKKRYVGFSYESPSQTLPIFDAKGIETVRRDGIPAQQKIIEKCIRLLFQT
KDLSKIKKYLQNEFFKIQIGKVSAQDFCFAKEVKLGAYKSEKTAPAGAVV
VKRRINEDHRAEPQYKERIPYLVVKGKQGQLLRERCVSPEEFLEGENLEL
DSEYYINKILIPPLDRLFNLIGINVGNWAQEICGEELKICSLCDDCLEKR
STTTLSFLIKKLKRQKEYQTLKTVCRTCSYRYTSDAGIENDHIASKCNSY
DCPVFYSRVKAERYLRDNQSVQREEALISLNDW
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8tlq Chain A Residue 1603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8tlq Cryo-EM structure of the Rev1-Pol zeta holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis.
Resolution3.53 Å
Binding residue
(original residue number in PDB)		P854 C1446 C1449 C1468 C1473 V1475 F1476
Binding residue
(residue number reindexed from 1)		P663 C1225 C1228 C1247 C1252 V1254 F1255
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0019985 translesion synthesis
GO:0042276 error-prone translesion synthesis
GO:0070987 error-free translesion synthesis
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0016035 zeta DNA polymerase complex
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8tlq, PDBe:8tlq, PDBj:8tlq
PDBsum8tlq
PubMed38720088
UniProtP14284|DPOZ_YEAST DNA polymerase zeta catalytic subunit (Gene Name=REV3)

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