Structure of PDB 8p4a Chain A Binding Site BS05

Receptor Information
>8p4a Chain A (length=1407) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCV
CFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNGGCGRYQP
RIRRSGLELYAEWKKKILLSPERVHEIFKRISDEECFVLGMEPRYARPEW
MIVTVLPVPPLSVRPAVRNQDDLTHKLADIVKINNQLRRNEQNGAAAHVI
AEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGN
LMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQ
ELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDG
DIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNADFDGDEMNL
HLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKRDV
FLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHINCI
RTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLV
HISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQ
NTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRILNDARDKTG
SSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRIPFGFK
HRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREGLIDTAVK
TAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGESVEF
QNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELE
REFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSD
LHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHLRSTLCSRR
MAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPATQMT
LNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAER
AKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVISPWLLRV
ELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRIMND
DDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKA
LQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKC
SFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKC
KYGMEIP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8p4a Chain A Residue 2003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8p4a Structural insights into human co-transcriptional capping.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		C71 C81 H84
Binding residue
(residue number reindexed from 1)		C61 C71 H74
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8p4a, PDBe:8p4a, PDBj:8p4a
PDBsum8p4a
PubMed37369200
UniProtA0A7M4DUC2

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