Structure of PDB 8p0k Chain A Binding Site BS05

Receptor Information
>8p0k Chain A (length=1277) Species: 10245 (Vaccinia virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVISKVTYSLYDQKEINATDIIISHVKNDDDIGTVKDGRLGAMDGALCKT
CGKTELECFGHWGKVSIYKTHIVKPEFISEIIRLLNHICIHCGLLRSREP
YSDDINLKELSGHALRRLKDKILSKKKSCWNSECMQPYQKITFSKKKVCF
VNKLDDINVPNSLIYQKLISIHEKFWPLLEIHQYPANLFYTDYFPIPPLI
IRPAISETNELTYLLGMIVKNCNLNADEQVIQKAVIEYDDIKIISNNTTS
INLSYITSGKNNMIRSYIVARRKDQTARSVIGPSTSITVNEVGMPAYIRN
TLTEKIFVNAFTVDKVKQLLASNQVKFYFNKRLNQLTRIRQGKFIKNKIH
LLPGDWVEVAVQEYTSIIFGRQPSLHRYNVIASSIRATEGDTIKISPGIA
NSQNADFDGDEEWMILEQNPKAVIEQSILMYPTTLLKHDIHGAPVYGSIQ
DEIVAAYSLFRIQDLCLDEVLNILGKYGREFDPKGKCKFSGKDIYTYLIG
EKINYPGLLKDGEIIANDVDSNFVVAMRHLSLAGLLSDHKSNVEGINFII
KSSYVFKRYLSIYGFGVTFKDLRPNSTFTNKLEAINVEKIELIKEAYAKY
LNDVRDGKIVPLSKALEADYVESMLSNLTNLNIREIEEHMRQTLIDDPDN
NLLKMAKAGYKVNPTELMYILGTYGQQRIDGEPAETRVLGRVLPYYLPDS
KDPEGRGYILNSLTKGLTGSQYYFSMLVARSQSTDIVCETSRTGTLARKI
IKKMEDMVVDGYGQVVIGNTLIKYAANYTKILGSVCKPVDLIYPDESMTW
YLEISALWNKIKQGFVYSQKQKLAKKTLAPFNFLVFVKPTTEDNAIKVKD
LYDMIHNVIDDVREKYFFTVSNIDFMEYIFLTHLNPSRIRITKETAITIF
EKFYEKLNYTLGGGTPIGIISAQVLSEKFTQQALSSFHTTEKSGAVKQKL
GFNEFNNLTNLSKNKTEIITLVSDDISKLQSVKINFEFVCLGELNPNITL
RKETDKYVVDIIVNRLYIKRAEITELVVEYMIERFISFSVIVKEWGMETF
IEDEDNIRFTVYLNFVEPEELNLSKFMMVLPGAANKGKISKFKIPISDYT
GYDDFNQTKKLNKMTVELMNLKELGSFDLENVNVYPGVWNTYDIFGIEAA
REYLCEAMLNTYGEGFDYLYQPCDLLASLLCASYEPESVNKFKFGAASTL
KRATFGDNKALLNAALHKKSEPINDNSSCHFFSKVPNIGTGYYKYFIDLG
LLMRMERKLSDKISSQKIKEMEETEDF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8p0k Chain A Residue 1303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8p0k Cryo EM map and model of the vaccinia RNA polymerase intermediate pre-initiation open promoter complex (CASP target)
Resolution2.64 Å
Binding residue
(original residue number in PDB)		C90 C93 C130 C135
Binding residue
(residue number reindexed from 1)		C89 C92 C129 C134
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0044423 virion component

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8p0k, PDBe:8p0k, PDBj:8p0k
PDBsum8p0k
PubMed
UniProtP20504|RP147_VACCC DNA-directed RNA polymerase 147 kDa polypeptide (Gene Name=OPG105)

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