Structure of PDB 8jxb Chain A Binding Site BS05

Receptor Information
>8jxb Chain A (length=244) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DTGTRCNQLQFTCLNGHCINQDWKCDNDNDCGDGSDELPTVCAFHTCRST
AFTCGNGRCVPYHYRCDYYNDCGDNSDEAGCLFRNCNSTTEFTCSNGRCI
PLSYVCNGINNCHDNDTSDEKNCPPHTCPPDFTKCQTTNICVPRAFLCDG
DNDCGDGSDENPIYCASHTCRSNEFQCLSPQRCIPSYWFCDGEADCADGS
DEPDTCGHSVNTCRASQFQCDNGRCISGNWVCDGDNDCGDMSDE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8jxb Chain A Residue 4708 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8jxb Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		W2883 D2886 E2888 D2890 D2896 E2897
Binding residue
(residue number reindexed from 1)		W188 D191 E193 D195 D201 E202
Annotation score4
External links
PDB RCSB:8jxb, PDBe:8jxb, PDBj:8jxb
PDBsum8jxb
PubMed38771880
UniProtP98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

[Back to BioLiP]