Structure of PDB 8jh4 Chain A Binding Site BS05

Receptor Information
>8jh4 Chain A (length=1400) Species: 460519 (Komagataella phaffii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQFPYSSAPLRSVKEVQFGLLSPEEIRAISVVKIEYPEIMDESRQRPREG
GLNDPKLGSIDRNFKCQTCGEGMAECPGHFGHMELAKPVFHIGFIPKIKK
VCECICMNCGKLLLDETNPTMAQAIRIRDPKKRFNAVWQLCKTKMVCCGN
TQPVVRKDGMKLWGTWKKSAQPERKLLTPGEILNVFKHISPEDCFRLGFN
EDYARPEWMIITVLPVPPPQVRPSIAMDETTQGQDDLTHKLSDILKANIN
VQKLEMDGSPQHIINEVEQLLQFHVATYMDNDIAGQPQALQKSGRPVKAI
RARLKGKEGRLRGNLMGKRVDFSARTVISGDPNLELDQVGVPISIAKTLS
YPETVTQYNIHRLTEYVRNGPNEHPGAKYVIRDNGDRIDLRYHKRAGDIV
LQYGWKVERHLMDDDPVLFNRQPSLHKMSMMAHRVKVMPYSTFRLNLSVT
SPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPVMGIVQ
DTLCGVRKMTLRDTFIEYEQVMNMLFWVPSWDGVVPQPAILKPKPLWTGK
QLLSIAIPSGIHLQRTDGGNSLLSPKDNGMLIVDGKVMFGVVDKKTVGSG
GGGLIHTVMREKGPKICAELFGNIQKVVNYWLLHNGFSIGIGDAIADAST
MKEITHAISSAKEQVQEIIYKAQHNELELKPGMTLRESFEGEVSRTLNDA
RDSAGRSAEMNLKDLNNVKQMVSAGSKGSFINIAQMSACVGQQMVEGKRI
AFGFADRSLPHFTKDDFSPESKGFVENSYLRGLTPQEFFFHAMAGREGLI
DTAVKTAETGYIQRRLVKALEDIMVHYDGTTRNSLGDIIQFLYGEDGLDG
TQVERQTIDTIPGSDKAFHKRYYVDLMDEKNSIKPDVIEYAADILGDVEL
QKELNSEYEQLVSDRKFLREIVFVNGDHNWPLPVNLRRIIQNAQQIFHLD
RAKASDLTIPEIIHGVRDLCKKLFVLRGENELIKEAQQNATSLFQCLVRA
RLATRRILEEFRLNRDAFEWVLGTIEAQFQRSLVHPGEMVGVIAAQSIGE
PATQMNVTLGVPRLKEILNVAKNIKTPALTVYLDREIALDIEKAKVIQSS
IEYTTLKNVTSATEIYYDPDPTSTVIEEDFDTVEAYFSQSPWLLRLELDR
ARMLDKQLTMNQVADKISEVFSDDLFVMWSEDNADKLIIRCRVIEEDQML
KRIEAHMLDLIALRGIPGISKVYMVKHKVSVPDESGEYKNEELWALETDG
INLAEVMAVPGVDSSRTYSNSFVEILSVLGIEATRSSLYKEILNVIAFDG
SYVNYRHMALLVDVMTSRGYLMAITRHGINRADTGALMRCSFEETVEILF
EAGAAAELDDCRGVSENVMLGQLAPMGTGAFDVMIDEKLLTSLPADYAPT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8jh4 Chain A Residue 1802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jh4 Cryo-EM structures of RNA polymerase II-nucleosome complexes rewrapping transcribed DNA
Resolution3.2 Å
Binding residue
(original residue number in PDB)		C107 C148 C168
Binding residue
(residue number reindexed from 1)		C106 C147 C148
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jh4, PDBe:8jh4, PDBj:8jh4
PDBsum8jh4
PubMed37981206
UniProtC4R4Y0

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